Results 61 to 70 of about 4,226,378 (303)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Doing Business and Country Reforms - An Independent Evaluation Group Issues Paper

open access: yes, 2021
This Issues Paper draws together evidence and initial analysis to propose a foundation and testable lines of inquiry for the Independent Evaluation Group (IEG) evaluation of the relevance and effectiveness of
Independent Evaluation Group
core   +1 more source

Location-Specific Orientation Set Is Independent of the Horizontal Benefit with or Without Object Boundaries

open access: yesVision, 2019
Chen and Cave (2019) showed that facilitation in visual comparison tasks that had previously been attributed to object-based attention could more directly be explained as facilitation in comparing two shapes that are configured horizontally rather than ...
Zhe Chen, Ailsa Humphries, Kyle R. Cave
doaj   +1 more source

Predicting QoS in LTE HetNets based on location-independent UE measurements [PDF]

open access: yes2015 IEEE 20th International Workshop on Computer Aided Modelling and Design of Communication Links and Networks (CAMAD), 2015
This paper aims to find patterns of knowledge from physical layer data coming from Heterogeneous Long Term Evolution (LTE) networks. We discuss how the collected data is employed in such a manner that improves Minimization of Drive Tests (MDT) functionality in LTE networks.
Moysen Cortes, Jessica   +3 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

High-precision robust broadband ultrasonic location and orientation estimation

open access: yes, 2009
This paper presents an indoor broadband ultrasonic system for estimation of a mobile device’s 3-D location and three-axis orientation using beacons. It presents the first implementation and characterization of a real frequency hopping spread spectrum ...
J. R. Gonzalez   +3 more
core   +1 more source

ISDC Reflections on Emerging One CGIAR Research Portfolio and Investment Plan [PDF]

open access: yes, 2021
The Executive Management Team (EMT) requested the Independent Science for Development Council (ISDC) to comment on the preliminary set of Research Initiatives.
CGIAR Independent Science for Development Council
core  

Location-Independent Organizations: Designing Collaboration Across Space and Time

open access: yesAdministrative Science Quarterly, 2021
Collaboration is critical to organizations and difficult when work is distributed. Prior research has indicated that when individuals are distributed, organizations respond by structuring their work to decrease reciprocal interdependence, reduce the complexity of tasks that individuals perform, or accept moderate inefficiencies.
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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