Results 71 to 80 of about 437,004 (256)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Elektronika ir Elektrotechnika, 2004 The overview of various location solutions such GSM and others technology represents in this paper. In the process of developinglocation based services are involved mobile network operators and the companies that produce the equipment and software. The mainconcerns about regulations are “privacy requirements” and “third party access to location data ...
V. Liutkauskas, D. Matulis, R. Plėštys
openaire +3 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Jurnal Teknologi dan Sistem Komputer, 2015 The University is an institution that has a role and strategic position in the achievement of educational goals. Semarang, as the center of Central Java has many universities, both public and private. The obstacles are that many students like high school
Satriaji Cahyo Nugroho +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Location Privacy Preservation for Mobile Users in Location-Based Services
IEEE Access, 2019 Because location-based cyber services are increasingly found in mobile applications (e.g., social networking and maps), user location privacy preservation is essential and remains one of the several ongoing research challenges.
Gang Sun +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Spatio-temporal aware privacy-preserving scheme in LBS
Tongxin xuebao, 2018 Location-based service (LBS) brings a lot of conveniences in people’s daily life,but the conveniences are accompanied with the leaking of privacy.A dummy-based location-preserving scheme was proposed,which took the correlation between spatial issues and ...
Weihao LI +3 more
doaj +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source