Results 91 to 100 of about 2,652,734 (290)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Spatio-temporal aware privacy-preserving scheme in LBS
Tongxin xuebao, 2018 Location-based service (LBS) brings a lot of conveniences in people’s daily life,but the conveniences are accompanied with the leaking of privacy.A dummy-based location-preserving scheme was proposed,which took the correlation between spatial issues and ...
Weihao LI +3 more
doaj +2 more sources
Optimal Bundle of Multimedia Services in Emerging Mobile Markets [PDF]
Although various emerging technologies have been launched, they present limitations as far as offering full-scale ubiquitous services independently is concerned.
Lee, ChanGi +3 more
core +1 more source
Mixed Data and Classification of Transit Stops
, 2016 An analysis of the characteristics and behavior of individual bus stops can reveal clusters of similar stops, which can be of use in making routing and scheduling decisions, as well as determining what facilities to provide at each stop.
Handley, John C. +2 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2009 This project carries out a part of a new location application. This service consists of location-based application that connects with a location server. That server provides the necessary location information to run the service. Then an interface between
Soler Vich, Josep Francesc
core +1 more source
Rethinking Location Privacy for Unknown Mobility Behaviors
, 2019 Location Privacy-Preserving Mechanisms (LPPMs) in the literature largely consider that users' data available for training wholly characterizes their mobility patterns.
Oya, Simon +2 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Working Report #1: Service Model Accessibility (Service Provider Perspectives) [PDF]
, 2009 This report examines the differences in service accessibility across central, integrated, and school/community based child welfare service delivery models including geographic proximity to families, acceptability of the setting to families, and ...
Cameron, Gary, Hazineh, Lirondel
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source