Results 51 to 60 of about 601,506 (267)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The efficiency of vehicle monitoring locations for a voluntary travel demand management program

Transport, 2014
As many people are concerned about sustainable urban transportation systems, Travel Demand Management (TDM) is getting more attention as a viable option to reduce automobile dependency on an efficient way. Especially, voluntary participation-based TDM by
Joonho Ko, Daejin Kim, Heung Gweon Sin, Seungjae Lee   +3 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Solving Weber Problem on Plane with Minimax Criterion and Forbidden Gaps

Известия Иркутского государственного университета: Серия "Математика", 2014
Location problems of various facilities are a wide class of operations research. The variety of statements of location problems is depends on the area in which are to be placed facilities and various restrictions and types of criteria. Important subclass
G.G. Zabudsky, N.S. Veremchuk
doaj  

A Deep Reinforcement Learning-Based Algorithm for Multi-Objective Agricultural Site Selection and Logistics Optimization Problem

Applied Sciences
The challenge of optimizing the distribution path for location logistics in the cold chain warehousing of fresh agricultural products presents a significant research avenue in managing the logistics of agricultural products.
Huan Liu, Jizhe Zhang, Zhao Zhou, Yongqiang Dai, Lijing Qin   +4 more
doaj   +1 more source

User-fair designing emergency service systems

Transport, 2019
The usual approach to emergency system design consists in deploying a given number of service centers to minimize the disutility perceived by an average user, what is called “min-sum” or “system approach”.
Jaroslav Janáček, Lýdia Gábrišová
doaj   +1 more source

The Coherent Covering Location Problem [PDF]

Papers in Regional Science, 1996
In a location-allocation system, it is necessary to obtain not only an efficient set of facility locations, but also an efficient relationship among the catchment areas. This is especially important in services that are hierarchical in nature and where there is a strong relationship between the different levels.
openaire   +3 more sources