Results 51 to 60 of about 585,264 (267)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The efficiency of vehicle monitoring locations for a voluntary travel demand management program
Transport, 2014 As many people are concerned about sustainable urban transportation systems, Travel Demand Management (TDM) is getting more attention as a viable option to reduce automobile dependency on an efficient way. Especially, voluntary participation-based TDM by
Joonho Ko +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Solving Weber Problem on Plane with Minimax Criterion and Forbidden Gaps
Известия Иркутского государственного университета: Серия "Математика", 2014 Location problems of various facilities are a wide class of operations research. The variety of statements of location problems is depends on the area in which are to be placed facilities and various restrictions and types of criteria. Important subclass
G.G. Zabudsky, N.S. Veremchuk
doaj
Applied SciencesThe challenge of optimizing the distribution path for location logistics in the cold chain warehousing of fresh agricultural products presents a significant research avenue in managing the logistics of agricultural products.
Huan Liu +4 more
doaj +1 more source
User-fair designing emergency service systems
Transport, 2019 The usual approach to emergency system design consists in deploying a given number of service centers to minimize the disutility perceived by an average user, what is called “min-sum” or “system approach”.
Jaroslav Janáček, Lýdia Gábrišová
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source