Results 31 to 40 of about 495 (252)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2002 application/pdf論文(Article)Locative Inversion is one of what is called "deep unaccusative diagnostics." However, close scrutiny of synchronic variations of Locative Inversion constructions makes an unaccusative analysis of it untenable and yields an ...
3024, MUNEMASA, Yoshihiro
core
Locativos preposicionados em posição de sujeito : uma possivel contribuição da línguas Bantu à sintaxe do português brasileiro [PDF]
Linguística, 2008 We observe the existing contrast between Brazilian and European Portuguese in relation to prepositional locatives in embedded sentences, and we argue that those constituents can occupy the grammatical subject position in transitive sentences in Brazilian
Juanito Avelar +3 more
doaj
Morphosyntactic variation in Bantu: The case of Setswana
Studies in African Linguistics, 2023 Within the context of microvariation in Bantu, three processes are examined in Setswana – object marking, inversion constructions and diminutive marking.
Nancy Kula, Lutz Marten
doaj
DELTA: Documentação de Estudos em Lingüística Teórica e Aplicada, 2007 Este artigo é uma compilação dos últimos cinco trabalhos de pós-graduação orientados por Lucia Lobato. Nossa meta é exemplificar dois temas recorrentes na linha de pesquisa desta lingüísta: (i) ênfase em traços lexicais e estruturais e (ii ...
Marcus Vinicius Lunguinho +4 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Notes on Deictic Inversion and Quotative Inversion in English [PDF]
, 2023 The peculiar syntactic and semantic properties of locative inversion (LI) have been a central research topic in the generative framework. It is argued that LI has a semantic/cognitive function of expressing a directly perceived situation that is about to
ホンダ, マサトシ +4 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Locative Inversion and Information Coherence
Korean Journal of English Language and Linguistics, 2016 This paper explores Locative Inversion (LI) in English. Following Kim (1998, 2000), we argue that the inverted locative PP is in fact an NP with a null head N. Consequently, we confirm Chomsky’s (1995) suggestion that it is only the nominal feature that enters into a checking relation with the EPP requirement of T.
null Kim, Yunhui, null Jeong-Seok Kim
openaire +1 more source