Results 41 to 50 of about 495 (252)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
In defence of the Discourse Intention feature
IsoglossThis paper investigates sentence-focus VS structures in Spanish and Catalan. It is generally assumed that, in Romance languages, a covert element occupies the canonical preverbal position, preventing the subject from moving there.
Núria Barrios Jurado
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
The Syntax of Speech Acts: Deictic Inversion as an Evidential Strategy in English
LanguagesThis paper presents empirical evidence to support the so-called syntactization of discourse, that is, the projection of relevant pragmatic features in the narrow syntax.
Ana Ojea
doaj +1 more source
The case of unaccusative mismatch in English [PDF]
Bucharest Working Papers in Linguistics, 2016 The paper examines the unaccusative-unergative dichotomy of predicates, with a special focus laid on the class status of the verb TO DIE in English. The paper begins with a view of unaccusativity in the light of the Lexicon-Syntax Interface. Further, the
Anna Dąbrowska
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
wiley +1 more source
Locative prepositions, predicate inversion and Full Interpretation*
, 2007 This paper studies the relation between the two structures in which Greek locative Prepositions participate. I investigate the possibility that Complex Preposition structures derive from the structure in which the locative is followed by a genitive ...
Terzi, Arhonto
core +1 more source
Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann +17 more
wiley +1 more source