Results 51 to 60 of about 12,931 (333)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Embodied memory and curatorship in children’s digital video production [PDF]
, 2010 Digital video production in schools is often theorised, researched and written about in two ways: either as a part of media studies practice or as a technological innovation, bringing new, “creative”, digital tools into the curriculum.
Potter, John
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Pràctiques artístiques basades en la localització que desafien la noció tradicional de cartografia
Artnodes, 2009 Els mitjans locatius constitueixen un camp emergent de pràctiques creatives i una plataforma per a provar noves experiències en l'entorn urbà que cada vegada interessa més als artistes.
Olga Paraskevopoulou +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
La scala della "città intelligente". Abitare lo spazio pubblico nella società delle Reti
Festival dell'Architettura Magazine, 2017 Al di là della dimensione puramente tecnocratica della prima generazione di progetti in materia di smart cities, e intendendo invece il settore di ricerca come complesso e crossdisciplinare, il lavoro cerca, su base storica, una interpretazione della ...
Rossella Ferorelli
doaj +1 more source
Locative media communities, social media and cultures of enthusiasm [PDF]
, 2022 Cristina Akemi Goldschmidt Kiminami +1 more
openalex +1 more source
Spatial Awareness in Locative Media Projects [PDF]
, 2016 This MRP focuses on the different applications that location technologies take part of such as, free based navigational systems like Google Maps, and Locative Media art projects; and analyzes their impact on people and their experience of space.
Ortiz, Claudia Andrea
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source