Results 161 to 170 of about 1,122 (295)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The construction of "Taishang zuo-zhe zhuxituan" in mandarin: a Cardiff grammar approach. [PDF]

Front Psychol
Xiang D.
europepmc   +1 more source

Dynamic Assessment for 3- and 4-Year-Old Children Who Use Augmentative and Alternative Communication: Evaluating Expressive Syntax. [PDF]

J Speech Lang Hear Res, 2017
Binger C, Kent-Walsh J, King M.
europepmc   +1 more source

New Insights Into Mouthings: Evidence From a Corpus-Based Study of Russian Sign Language. [PDF]

Front Psychol, 2021
Bauer A, Kyuseva M.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Animacy, postpositions, and the spatial cases in Niya Prakrit. [PDF]

J South Asian Lang Linguist
Schoubben N.
europepmc   +1 more source

Do Children with SLI Use Verbs to Predict Arguments and Adjuncts: Evidence from Eye Movements During Listening. [PDF]

Front Psychol, 2015
Andreu L, Sanz-Torrent M, Rodríguez-Ferreiro J.   +2 more
europepmc   +1 more source

Does narrator variability facilitate incidental word learning in the classroom? [PDF]

Mem Cognit, 2022
Tapia JL, Rosa E, Rocabado F, Vergara-Martínez M, Perea M.   +4 more
europepmc   +1 more source

A pragmatic explanation of the stage level/individual level contrast in combination with locatives

, 2004
One important difference between stage level predicates (SLPs) and individual level predicates (ILPs) is their behavior with respect to locative modifiers. It is commonly assumed that SLPs but not ILPs combine with locatives.
Maienborn, Claudia
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source