Results 141 to 150 of about 1,473 (283)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Inner and Outer Locatives in Korea [PDF]
, 1973 In Korean, inner and outer locatives are indicated by the postpositions e and esa respectively: (1) (a) na-ka chako -e nae cha-lil tu -nin -ta I SM garage IL my car OM keep PRES DEC 1 'I keep my car in the garage.' (b) na-ka chako ...
Yang, Dong-Whee
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Semantics of Locatives in the Uralic Languages
, 2005 Kracht M. The Semantics of Locatives in the Uralic Languages. In: Fernandez-Vest J, ed. Les languages ouraliennes aujourd'hui. Approche linguistics et cognitive. Bibilothèque de l'Ecole des Hautes Etudes, Sciences Historiques et Philologiques.
Kracht, Marcus, Fernandez-Vest, Jocelyne
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Multi-variate coding for possession: methodology and preliminary results. [PDF]
Linguistics, 2023 Chousou-Polydouri N +3 more
europepmc +1 more source
The semantic representation of locatives in machine translation [PDF]
, 2004 (1) Musa løp under bordet. 'The mouse ran under the table.' (2) Under bordet er et fint sted å gjemme seg. 'Under the table is a good place to hide.' Locative prepositional phrases, as seen in (1) and (2) ('under bordet'), all express spatial ...
Jørgensen, Fredrik
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source