Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The construction of "Taishang zuo-zhe zhuxituan" in mandarin: a Cardiff grammar approach. [PDF]
Front PsycholXiang D.
europepmc +1 more source
Dynamic Assessment for 3- and 4-Year-Old Children Who Use Augmentative and Alternative Communication: Evaluating Expressive Syntax. [PDF]
J Speech Lang Hear Res, 2017 Binger C, Kent-Walsh J, King M.
europepmc +1 more source
Does narrator variability facilitate incidental word learning in the classroom? [PDF]
Mem Cognit, 2022 Tapia JL +4 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Animacy, postpositions, and the spatial cases in Niya Prakrit. [PDF]
J South Asian Lang LinguistSchoubben N.
europepmc +1 more source
Do Children with SLI Use Verbs to Predict Arguments and Adjuncts: Evidence from Eye Movements During Listening. [PDF]
Front Psychol, 2015 Andreu L +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Étude de faisabilité du dispositif « Passerelle » couplant transfert monétaire non fléché et orientation sociale destiné à des ménages en situation de précarité en France. [PDF]
Can J Public HealthGallinari-Safar P +11 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source