Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Exploring Assumptions of the Bilingual Delay in Children With and Without Developmental Language Disorder. [PDF]
J Speech Lang Hear Res, 2023 Peña ED, Bedore LM, Vargas AG.
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Error patterns and revisions in the graphic symbol utterances of 3- and 4-year-old children who need augmentative and alternative communication. [PDF]
Augment Altern Commun, 2019 Binger C +4 more
europepmc +1 more source
What's New? Gestures Accompany Inferable Rather Than Brand-New Referents in Discourse. [PDF]
Front Psychol, 2020 Debreslioska S, Gullberg M.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Uso temporal de algunos marcadores de localización espacial en español y en francés
Études romanes de Brno, 2013 The objective of this speech is to present time uses of some space location markers, in Spanish and French. The possibility of using the same elements for the space and time location confirms the existence of a very strong connection between these two ...
Beata Brzozowska-Zburzyńska
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A Conceptual Restructuring of Spatial Motion Expressions in Chinese L2. [PDF]
Front Psychol, 2018 Sparvoli C.
europepmc +1 more source