Results 91 to 100 of about 1,473 (282)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The Points Of Language

open access: yesHumana.Mente: Journal of Philosophical Studies, 2013
Signed languages display a variety of pointing signs that serve the functions of deictic and anaphoric pronouns, possessive and reflexive pronouns, demonstratives, locatives, determiners, body part labels, and verb agreement.
Richard P. Meier, Diane Lillo-Martin
doaj  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The case of restricted locatives [PDF]

open access: yes, 2019
International audienceThis paper examines the cross-linguistic phenomenon of locative case restricted to a closed class of items (L-nouns). Starting with Latin, I suggest that the restriction is semantic in nature: L-nouns denote in the spatial domain ...
Matushansky, Ora
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Rytą or ryte? Vakarą or vakare? A corpus analysis of Lithuanian time expressions denoting parts of the day

open access: yesKalbotyra
This paper aims to reveal differences between the competing accusative and locative forms of Lithuanian temporal expressions denoting parts of the day (rytas ‘morning’, diena ‘day’, vakaras ‘evening’, naktis ‘night’).
Nina Kapušová
doaj   +3 more sources

Alain Peyraube : Les constructions locatives en chinois moderne

open access: yes, 1980
Paris Marie-Claude. Alain Peyraube : Les constructions locatives en chinois moderne. In: Cahiers de linguistique - Asie orientale, vol. 8, 1980. pp.
Paris, Marie-Claude
core   +1 more source

Mobilité résidentielle et logique des itinéraires vers la périphérie Boudiouck de Saint-Louis (Sénégal) [PDF]

open access: yesRevue de Géographie Tropicale et d’Environnement
Saint-Louis, ville tricentenaire et située dans le nord-ouest du Sénégal, est dans un processus d’urbanisation irréversible. Ses quartiers historiques, souvent mal planifiés et situés sur un site fragile, souffrent de nombreux dysfonctionnements.
Lamine Ousmane CASSÉ
doaj   +1 more source

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