Results 41 to 50 of about 5,282,744 (302)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

PyThermLIA: A Python library to implement digital lock-in processing

open access: yesSoftwareX
PyThermLIA is a free and open-source Python library that implements a Digital Lock-in Amplifier for processing videos recorded by generic digital cameras.
E. Vargas   +5 more
doaj   +1 more source

The political philosophy of John Locke [PDF]

open access: yesUniverzitetska Misao, 2017
John Lock is one of the most influential philosophers of modern age. In his writings, he claimed that all men were free and equal in front of God, and in that direction he endeavored to rebel the claims that God created men to be subordinate to the will ...
Bećirović-Alić Maida
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

From ultra-noisy to ultra-stable: Optimization of the optoelectronic laser lock [PDF]

open access: yesAPL Photonics
We demonstrate the direct locking of a 820 kHz linewidth semiconductor distributed feedback laser to a high finesse, compact, and ultrastable reference cavity using the optoelectronic (OEO) laser locking method, resulting in cavity thermal noise-limited ...
Takuma Nakamura   +7 more
doaj   +1 more source

Galloping and VIV control of square-section cylinder utilizing direct opposing smart control force [PDF]

open access: yesJournal of Theoretical and Applied Vibration and Acoustics, 2019
An adaptive fuzzy sliding mode controller (AFSMC) is adopted to reduce the 2D flow-induced vibration of an elastically supported square-section cylinder, free to oscillate in stream-wise andtransverse directions in both lock-in and galloping regions. The
Amir Hossein Rabiee
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Rancang Bangun Alat Pengembalian Buku Perpustakaan Secara Mandiri Berbasis Single Board Computer

open access: yesCHIPSET, 2023
the process of borrowing and returning library books usually requires a librarian to go through this process, of course this requirement can cause delays in returning books due to library holidays and the difference in free hours from the library and ...
Nazri Ilhamzah Akbar   +2 more
doaj   +1 more source

Lock-free concurrent binomial heaps [PDF]

open access: yesJournal of Logical and Algebraic Methods in Programming, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

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