Results 61 to 70 of about 179,232 (292)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Functional Genetic Screen to Identify Interneurons Governing Behaviorally Distinct Aspects of Drosophila Larval Motor Programs

G3: Genes, Genomes, Genetics, 2016
Drosophila larval crawling is an attractive system to study rhythmic motor output at the level of animal behavior. Larval crawling consists of waves of muscle contractions generating forward or reverse locomotion.
Matt Q. Clark, Stephanie J. McCumsey, Sereno Lopez-Darwin, Ellie S. Heckscher, Chris Q. Doe   +4 more
doaj   +1 more source

Trabecular bone structure correlates with hand posture and use in hominoids [PDF]

, 2013
Bone is capable of adapting during life in response to stress. Therefore, variation in locomotor and manipulative behaviours across extant hominoids may be reflected in differences in trabecular bone structure.
Gross, Thomas, Kivell, Tracy L., Nguyen, N Huynh, Pahr, Dieter H, Skinner, Matthew M, Smaers, Jeroen B, Tsegai, Zewdi J.   +6 more
core   +4 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Locomotion as a Measure of Well-Being in Captive Chimpanzees (Pan troglodytes)

Animals, 2023
Locomotion in non-human primates, including walking, climbing, and brachiating among other types of movement (but not pacing), is a species-typical behavior that varies with age, social housing conditions, and environmental factors (e.g., season, food ...
Sarah Neal Webb, Steven Schapiro
doaj   +1 more source

Hand and foot pressures in the aye-aye (Daubentonia madagascariensis) reveal novel biomechanical trade-offs required for walking on gracile digits [PDF]

, 2010
Arboreal animals with prehensile hands must balance the complex demands of bone strength, grasping and manipulation. An informative example of this problem is that of the aye-aye (Daubentonia madagascariensis), a rare lemuriform primate that is unusual ...
Ancrenaz, Ashton, Cartmill, Cartmill, Cartmill, Curtis, D'Août, Demes, Dutto, Elftman, Erickson, Flannery, Gebo, Hamrick, Hunt, Inouye, Jouffroy, Jouffroy, Jouffroy, Kimura, Kimura, Krakauer, Lammers, Lammers, Lee, Lemelin, Lemelin, Lemelin, Lemelin, Lemelin, Lemelin, Lessertisseur, Milliken, Napier, Napier, Owen, Oxnard, Oxnard, Patel, Patel, Preuschoft, Preuschoft, Prost, Quinn, Raichlen, Raichlen, Reynolds, Richmond, Schaal, Scheumann, Schmitt, Schmitt, Simons, Soligo, Sterling, Strasser, Strasser, Susman, Swartz, Tuttle, Tuttle, Vereecke, Vereecke, Vilensky, Wunderlich, Wunderlich, Wunderlich   +66 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Smed-dynA-1 is a planarian nervous system specific dynamin 1 homolog required for normal locomotion

Biology Open, 2014
Dynamins are GTPases that are required for separation of vesicles from the plasma membrane and thus are key regulators of endocytosis in eukaryotic cells. This role for dynamin proteins is especially crucial for the proper function of neurons, where they
Jared A. Talbot, Ko W. Currie, Bret J. Pearson, Eva-Maria S. Collins   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Development of equation of motion deciphering locomotion including omega turns of Caenorhabditis elegans

eLife
Locomotion is a fundamental behavior of Caenorhabditis elegans (C. elegans). Previous works on kinetic simulations of animals helped researchers understand the physical mechanisms of locomotion and the muscle-controlling principles of neuronal circuits ...
Taegon Chung, Iksoo Chang, Sangyeol Kim
doaj   +1 more source