Results 221 to 230 of about 31,706 (269)

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen   +5 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

open access: yesAdvanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang   +19 more
wiley   +1 more source

Locomotive Syndrome (Disorders of the Locomotive Organs)

open access: yesJOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE, 2012
openaire   +2 more sources
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The allometry of locomotion

Ecology, 2021
Abstract Organismal locomotion mediates ecological interactions and shapes community dynamics. Locomotion is constrained by intrinsic and environmental factors and integrating these factors should clarify how locomotion affects ecology across scales. We extended general theory based on metabolic scaling and biomechanics to predict the
Carl S. Cloyed   +4 more
openaire   +2 more sources

Locomotion of bluefish

Journal of Experimental Zoology, 1976
Abstract Pressures previously measured on the body surface of swimming bluefish were resolved into their backward vectorial components to allow calculation of profile drag. It was 0.18 kg at a speed of 1.8 m/sec. Tangential drag was calculated as if for a thin plate of an area equal to that of the fish. It was 0.08 kg at 1.8 m/sec.
A. B. DuBois, G.A. Cavagna, R. S. Fox
openaire   +3 more sources

Chemical Locomotion

Angewandte Chemie International Edition, 2006
AbstractResearch into the autonomous motion of artificial nano‐ and microscale objects provides basic principles to explore possible applications, such as self‐assembly of superstructures, roving sensors, and drug delivery. Although the systems described have unique propulsion mechanisms, motility in each case is made possible by the conversion of ...
Walter F, Paxton   +3 more
openaire   +2 more sources

Locomotion in caterpillars

Biological Reviews, 2014
ABSTRACTMost species of caterpillar move around by inching or crawling. Their ability to navigate in branching three‐dimensional structures makes them particularly interesting biomechanical subjects. The mechanism of inching has not been investigated in detail, but crawling is now well understood from studies on caterpillar neural activity, dynamics ...
L I, van Griethuijsen, B A, Trimmer
openaire   +2 more sources

Locomotion and nightwaking

Child: Care, Health and Development, 2005
Abstractobjective  In this study we addressed the association between two major achievements of infancy: independent locomotion and ‘sleeping through the night’ .Methods  Mothers of 107 healthy infants aged between five and eight months completed a sleep questionnaire and a motor checklist.Results and Conclusions  Infants who were already crawling had ...
A, Scher, D, Cohen
openaire   +2 more sources

Pygmy locomotion

European Journal of Applied Physiology and Occupational Physiology, 1994
The hypothesis that Pygmies may differ from Caucasians in some aspects of the mechanics of locomotion was tested. A total of 13 Pygmies and 7 Caucasians were asked to walk and run on a treadmill at 4-12 km.h-1. Simultaneous metabolic measurements and three-dimensional motion analysis were performed allowing the energy expenditure and the mechanical ...
MINETTI A. E.   +5 more
openaire   +4 more sources

The Locomotion of Nematodes

Journal of Experimental Biology, 1964
ABSTRACT The form and frequency of the waves passing down the bodies of small free-living nematodes (Panagrellus, Rhabditis and Turbatrix) depend on the nature of the external medium. Observations of animals moving in such media as syrup, agar gels, and dense suspensions of particles suggest that the relationship between the speed of ...
J, GRAY, H W, LISSMANN
openaire   +2 more sources

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