Results 231 to 240 of about 116,818 (311)

ME-BYO index as a formative construct for healthy ageing: a cross-sectional PLS-SEM analysis. [PDF]

Sci Rep
Nakamura S, Watanabe K, Chei CL, Feng L, Ye KX, Lim KX, Watanabe R, Chung UI, Narimatsu H.   +8 more
europepmc   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Changes in Physical Function and Locomotive Syndrome Status in the Postoperative Period Following Total Hip and Knee Arthroplasty. [PDF]

Cureus
Takenaka H, Ida K, Kawamura M.
europepmc   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Representation of locomotive action affordances in human behavior, brains, and deep neural networks. [PDF]

Proc Natl Acad Sci U S A
Bartnik CG, Sartzetaki C, Sanchez AP, Molenkamp E, Bommer S, Vukšić N, Groen IIA.   +6 more
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Enhancing Recovery in Geriatric Spine Surgery: From Risk Prediction to Patient Preparation. [PDF]

Geriatr Gerontol Int
Huang CC.
europepmc   +1 more source

Output, Employment, and Productivity in the United States after 1800 [PDF]

Albert Fishlow
core  

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Effects of Lower Limb-Focused Low-Intensity Resistance Exercise Using Slow Movements on Locomotive Syndrome in Patients with Type 2 Diabetes Mellitus. [PDF]

Medicina (Kaunas)
Morihara T, Hisamoto K, Okubo N, Fukushima H, Matsui T, Hiramoto M, Hamaguchi M, Okada H, Matsui T, Imai D, Fukui M, Takahashi K.   +11 more
europepmc   +1 more source