Results 31 to 40 of about 31,706 (269)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Evaluation Model of Loop Stray Parameters for Energy Storage Converter of Hybrid Electric Locomotive

IEEE Access, 2020
When the silicon carbide (SiC) power module is applied to the energy storage converter of a hybrid locomotive, under the action of di/dt and loop stray inductance, it is easy to produce excessively high voltage overshoot, which affects the battery life ...
Yunxin Fan, Wang Li, Bo Liu, Miaoxin Jin, Xiaoyu Ren, Chunmei Xu, Lijun Diao   +6 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Aerodynamic Characteristics of City Railway Train at the Sudden Variable Tunnel Cross-Section Positions

Chengshi guidao jiaotong yanjiu
［Objective］In order to ensure train operation safety and passenger comfort, it is necessary to study the chang-ing laws of aerodynamic force and pressure inside the city railway train when passing through the variable cross-section positions in the ...
ZHANG Baozhen, XIE Hongbing, MENG Lingfeng, DAI Longming, NAN Zhe, XIONG Xiaohui   +5 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

The “Garratt” Locomotive [PDF]

Journal of the Institution of Locomotive Engineers, 1916
n ...
openaire   +2 more sources

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Research on Multi-System Integration Control for Urban Rail Transit Train Based on Time-Sensitive Networks

Chengshi guidao jiaotong yanjiu
[Objective] The architecture of traditional urban rail transit train control system faces challenges such as complex train network topology and wiring, increased delays in subsystem interactions, and poor coordination in complex control processes.
YANG Weijun, LI Yangtao, XUE Jiang, MEN Hongfang, LI Liran, ZHANG Zherui   +5 more
doaj   +1 more source

A Locomotive Grading Servicing Scheme Based on LMD System

Kongzhi Yu Xinxi Jishu, 2023
In order to automatically calculate the running mileage of the locomotive and prompt the corresponding servicing level according to the running mileage, this paper proposes a locomotive grading servicing scheme based on the LMD system.
SHI Hanbo, DENG Guozhi, LUO Hao
doaj   +1 more source