Screening of Endophytic Fungi in Locoweed Induced by Heavy-Ion Irradiation and Study on Swainsonine Biosynthesis Pathway [PDF]
Journal of Fungi, 2022 Swainsonine (SW) is a substance with both animal neurotoxicity and natural anticancer activity produced by the metabolism of endophytic fungus Alternaria section Undifilum oxytropis of locoweed.
Yanan Mo +11 more
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Transcriptomic Screening of Alternaria oxytropis Isolated from Locoweed Plants for Genes Involved in Mycotoxin Swaisonine Production [PDF]
Journal of FungiLocoweed is a collective name for a variety of plants, such as Oxytropis and Astragalus L. When these plants are infected by some fungi or endophytes, they will produce an alkaloid (swainsonine) that is harmful to livestock.
Shuangjie Yuan +6 more
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Rethinking of the Roles of Endophyte Symbiosis and Mycotoxin in Oxytropis Plants [PDF]
Journal of Fungi, 2021 Plants in the Oxytropis genus can live with the endophytic fungi Alternaria sect. Undifilum. Swainsonine, the mycotoxin produced by the endophyte render the host plant toxic and this has been detrimental to grazing livestock in both China and U.S.A ...
Huirui Guan +6 more
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Predicting the distribution of suitable habitat of the poisonous weed Astragalus variabilis in China under current and future climate conditions [PDF]
Frontiers in Plant Science, 2022 Astragalus variabilis is a locoweed of northwest China that can seriously impede livestock development. However, it also plays various ecological roles, such as wind protection and sand fixation.
Ruijie Huang +15 more
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Construction of Yeast One-Hybrid Library of Alternaria oxytropis and Screening of Transcription Factors Regulating swnK Gene Expression [PDF]
Journal of Fungi, 2023 The indolizidine alkaloid-swainsonine (SW) is the main toxic component of locoweeds and the main cause of locoweed poisoning in grazing animals. The endophytic fungi, Alternaria Section Undifilum spp., are responsible for the biosynthesis of SW in ...
Jiaqi Xue +6 more
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Host-Specific and Environment-Dependent Effects of Endophyte Alternaria oxytropis on Three Locoweed Oxytropis Species in China [PDF]
Journal of FungiPlant–endophyte symbioses are widespread in grasslands. While symbiotic interactions often provide hosts with major fitness enhancements, the role of the endophyte Alternaria oxytropis, which produces swainsonine in locoweeds (Oxytropis and Astragalus ...
Yue-Yang Zhang, Yan-Zhong Li, Zun-Ji Shi
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Metabolomic analysis of swainsonine poisoning in renal tubular epithelial cells [PDF]
Frontiers in Veterinary ScienceLocoweed is a poisonous plant widely present in grasslands around the world. Swainsonine (SW), an indole alkaloid that, is the main toxic component of the locoweed. To understand the mechanism of SW-induced toxicity and to delineate the metabolic profile
Shuhang Zhang +9 more
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siRNA-Silencing of swnR gene greatly reduced biosynthesis of swainsonine in Alternaria oxytropis without affecting the growth characteristics of leguminous host [PDF]
Frontiers in MicrobiologyLocoism refers to a neurological disorder in livestock caused by chronic ingestion of locoweeds, which contain toxic alkaloid swainsonine produced by the fungus Alternaria oxytropis.
Yu Zhang +6 more
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A Review of Intermittent Poisoning to Mitigate Toxic Plant-Induced Disease in Livestock [PDF]
Veterinary SciencesPoisonous plants affect livestock and wildlife and in addition to animal disease, they often inhibit the productive use of feeds and natural resources. For some plants, intermittent or cyclic grazing may allow the use of contaminated forages or infested ...
Bryan L. Stegelmeier +4 more
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Environmental Drivers Override Host Phylogeny in a Locoweed–Endophyte Symbiosis [PDF]
Journal of FungiPlant endophytes, often termed the “second genome”, critically shape host adaptability. However, the complexity of their interactions, regulated by microbial traits, host species, and environment, has limited both our understanding of symbiosis and the ...
Yue-Yang Zhang +2 more
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