Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression [PDF]
BMC Cancer, 2019 Background Swainsonine is a natural indolizidine alkaloid, its anti-tumor activity has been widely reported in varied cancers. This study aimed to investigate whether Swainsonine exerted anti-tumor impact on glioma cells, likewise uncovered the relative ...
Libo Sun +5 more
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Assessing the Biogeographic Risks of Potentially Toxic Plants-A Case Study for a Novel Locoweed <i>Sphaerophysa salsula</i> in China. [PDF]
Ecol EvolThis study firstly identified the toxic principles of S. salsula and proposed a MaxEnt model to predict its suitable habitats and assess livestock poisoning risks under various SSP scenarios. ABSTRACT Climate change‐induced grassland degradation has exacerbated the spread of toxic plants, yet many potentially toxic species remain overlooked ...
Zhang YY +4 more
europepmc +2 more sources
siRNA-Silencing of swnR gene greatly reduced biosynthesis of swainsonine in Alternaria oxytropis without affecting the growth characteristics of leguminous host [PDF]
Frontiers in MicrobiologyLocoism refers to a neurological disorder in livestock caused by chronic ingestion of locoweeds, which contain toxic alkaloid swainsonine produced by the fungus Alternaria oxytropis.
Yu Zhang +6 more
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Endophytic Alternaria oxytropis modulates host metabolism and enhances stress resilience in locoweed independent of swainsonine biosynthesis [PDF]
BMC Plant BiologyLocoweed toxicity is attributed to swainsonine-producing endophytic fungus Alternaria oxytropis, yet the broader ecological significance of fungal metabolites beyond swainsonine remains poorly understood.
Yu Zhang +7 more
doaj +2 more sources
Feed-induced hypersalivation in horses from Austria, Germany and Switzerland. [PDF]
Equine Vet JAbstract Background While previous reports come mostly from the southern Americas, several outbreaks of hypersalivation in horses were observed in Middle Europe from 2016 to 2018. Objective To describe feed‐induced hypersalivation in European horses. Study design Analysis of feedstuffs.
Böswald LF +5 more
europepmc +2 more sources
Phylogenetic Patterns of Swainsonine Presence in Morning Glories
Frontiers in Microbiology, 2022 Endosymbionts play important roles in the life cycles of many macro-organisms. The indolizidine alkaloid swainsonine is produced by heritable fungi that occurs in diverse plant families, such as locoweeds (Fabaceae) and morning glories (Convolvulaceae ...
Quynh N. Quach +3 more
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Analysis of the Mycotoxin Levels and Expression Pattern of SWN Genes at Different Time Points in the Fungus Slafractonia leguminicola [PDF]
MicroorganismsThe fungal plant pathogen Slafractonia leguminicola produces two mycotoxins that affect animals: slaframine, which causes slobbers, and swainsonine, which causes locoism.
Sumanjari Das +3 more
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Environmental Drivers Override Host Phylogeny in a Locoweed–Endophyte Symbiosis [PDF]
Journal of FungiPlant endophytes, often termed the “second genome”, critically shape host adaptability. However, the complexity of their interactions, regulated by microbial traits, host species, and environment, has limited both our understanding of symbiosis and the ...
Yue-Yang Zhang +2 more
doaj +2 more sources
Development of Novel Formulation for Sustained Release of Drug to Prevent Swainsonine-Containing Plants Poisoning in Livestock [PDF]
Animals, 2023 Swainsonine-containing plants contain swainsonine which has been shown to cause neurological signs and pathological changes in farm animals. It causes a large number of livestock poisonings every year resulting in economic losses to the livestock ...
Bo Li +7 more
doaj +2 more sources
The Effect of the swnR Gene on Swainsonine Biosynthesis in Alternaria oxytropis OW7.8, an Endophytic Fungus of Oxytropis glabra [PDF]
MicroorganismsThe swnR gene was cloned in the endophytic fungus Alternaria oxytropis OW 7.8 isolated from Oxytropis glabra, and the gene knockout mutant ΔswnR was first constructed in this study. Compared with A.
Ning Ding +4 more
doaj +2 more sources