siRNA-Silencing of swnR gene greatly reduced biosynthesis of swainsonine in Alternaria oxytropis without affecting the growth characteristics of leguminous host [PDF]
Frontiers in MicrobiologyLocoism refers to a neurological disorder in livestock caused by chronic ingestion of locoweeds, which contain toxic alkaloid swainsonine produced by the fungus Alternaria oxytropis.
Yu Zhang +6 more
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Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression [PDF]
BMC Cancer, 2019 Background Swainsonine is a natural indolizidine alkaloid, its anti-tumor activity has been widely reported in varied cancers. This study aimed to investigate whether Swainsonine exerted anti-tumor impact on glioma cells, likewise uncovered the relative ...
Libo Sun +5 more
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Endophytic Alternaria oxytropis modulates host metabolism and enhances stress resilience in locoweed independent of swainsonine biosynthesis [PDF]
BMC Plant BiologyLocoweed toxicity is attributed to swainsonine-producing endophytic fungus Alternaria oxytropis, yet the broader ecological significance of fungal metabolites beyond swainsonine remains poorly understood.
Yu Zhang +7 more
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Analysis of the Mycotoxin Levels and Expression Pattern of SWN Genes at Different Time Points in the Fungus Slafractonia leguminicola [PDF]
MicroorganismsThe fungal plant pathogen Slafractonia leguminicola produces two mycotoxins that affect animals: slaframine, which causes slobbers, and swainsonine, which causes locoism.
Sumanjari Das +3 more
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Environmental Drivers Override Host Phylogeny in a Locoweed–Endophyte Symbiosis [PDF]
Journal of FungiPlant endophytes, often termed the “second genome”, critically shape host adaptability. However, the complexity of their interactions, regulated by microbial traits, host species, and environment, has limited both our understanding of symbiosis and the ...
Yue-Yang Zhang +2 more
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Host-Specific and Environment-Dependent Effects of Endophyte Alternaria oxytropis on Three Locoweed Oxytropis Species in China [PDF]
Journal of FungiPlant–endophyte symbioses are widespread in grasslands. While symbiotic interactions often provide hosts with major fitness enhancements, the role of the endophyte Alternaria oxytropis, which produces swainsonine in locoweeds (Oxytropis and Astragalus ...
Yue-Yang Zhang, Yan-Zhong Li, Zun-Ji Shi
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The Effect of the swnR Gene on Swainsonine Biosynthesis in Alternaria oxytropis OW7.8, an Endophytic Fungus of Oxytropis glabra [PDF]
MicroorganismsThe swnR gene was cloned in the endophytic fungus Alternaria oxytropis OW 7.8 isolated from Oxytropis glabra, and the gene knockout mutant ΔswnR was first constructed in this study. Compared with A.
Ning Ding +4 more
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Metabolomic analysis of swainsonine poisoning in renal tubular epithelial cells [PDF]
Frontiers in Veterinary ScienceLocoweed is a poisonous plant widely present in grasslands around the world. Swainsonine (SW), an indole alkaloid that, is the main toxic component of the locoweed. To understand the mechanism of SW-induced toxicity and to delineate the metabolic profile
Shuhang Zhang +9 more
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The Effects of P5CR Gene Function of Endophytic Fungus Alternaria oxytropis OW7.8 on Swainsonine Biosynthesis [PDF]
BiomoleculesLocoweeds, including Oxytropis and Astragalus species, are globally recognized as plants containing swainsonine (SW), a neurotoxic alkaloid that induces neurological dysfunction and growth inhibition in livestock.
Fan Yang +8 more
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Morphological and Phylogenetic Characterization of Alternaria Section Undifilum Fungal Endophytes from Astragalus and Swainsona spp. [PDF]
Journal of FungiThe locoweeds Astragalus and Oxytropis in the Americas and China, as well as Swainsona in Australia, harbor swainsonine-producing endophytes responsible for “locoism” or “pea struck” syndromes in grazing animals.
Marwa Neyaz +3 more
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