Results 41 to 50 of about 1,931 (193)

TOTAL SYNTHESIS OF SWAINSONINE [PDF]

Chemistry Letters, 1984
Abstract Swainsonine, a potential immunoregulator, was synthesized from d-mannose via an intermediate, methyl 4,8-imino-2,3-O-isopropylidene-4,6,7,8-tetradeoxy-α-d-manno-octopyranoside.
Nobuyoshi Yasuda, Hideo Tsutsumi, Takao Takaya   +2 more
openaire   +1 more source

ChemInform Abstract: Syntheses of (‐)‐8‐epi‐Swainsonine and (‐)‐1,8‐Di‐epi‐swainsonine, Stereoisomers of Physiologically Interesting Indolizidine Alkaloid, Swainsonine. [PDF]

ChemInform, 1987
AbstractThe glucopyranoside (I) is transformed to (‐)‐8‐epi‐swainsonine (VII) as shown in the scheme.
K. TADANO, Y. IIMURA, Y. HOTTA, C. FUKABORI, T. SUAMI   +4 more
openaire   +2 more sources

Alpha-mannosidosis caused by toxic plants in ruminants of Argentina

Anais da Academia Brasileira de Ciências, 2021
It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country.
LUCIANA A. CHOLICH, AGUSTÍN MARTINEZ, JUAN F. MICHELOUD, MARÍA E. PISTÁN, ENRIQUE N. GARCÍA, CARLOS A. ROBLES, HUGO H. ORTEGA, EDUARDO J. GIMENO   +7 more
doaj   +1 more source

Data_Sheet_1_Phylogenetic Patterns of Swainsonine Presence in Morning Glories.docx

, 2022
Endosymbionts play important roles in the life cycles of many macro-organisms. The indolizidine alkaloid swainsonine is produced by heritable fungi that occurs in diverse plant families, such as locoweeds (Fabaceae) and morning glories (Convolvulaceae ...
Daniel Cook (405350), Keith Clay (316577), Dale R. Gardner (616372), Quynh N. Quach (12491698)   +3 more
core   +1 more source

Biomarkers and their potential for detecting livestock plant poisonings in Western North America

Frontiers in Veterinary Science, 2023
The United States National Cancer Institute defines a biomarker as: “A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease.” In Veterinary Medicine, biomarkers ...
Benedict T. Green, Kevin D. Welch, Stephen T. Lee, Clinton A. Stonecipher, Dale R. Gardner, Bryan L. Stegelmeier, T. Zane Davis, Daniel Cook   +7 more
doaj   +1 more source

The study of metabolites from fermentation culture of Alternaria oxytropis

BMC Microbiology, 2019
Background The indolizidine alkaloid-swainsonine is produced by an endophytic fungus Alternaria oxytropis, which was isolated from locoweeds. Swainsonine has many biological activities such as anti-tumorigenic, anti-viral and bacteriostatic. However, the
Runjie Song, Jinglong Wang, Lu Sun, Yajing Zhang, Zhenghui Ren, Baoyu Zhao, Hao Lu   +6 more
doaj   +1 more source

Localization of the Swainsonine-Producing Chaetothyriales Symbiont in the Seed and Shoot Apical Meristem in Its Host Ipomoea carnea

Microorganisms, 2022
Several species of fungi from the orders Chaetothyriales and Pleosporales have been reported to produce swainsonine and be associated as symbionts with plants of the Convolvulaceae and Fabaceae, respectively.
Marwa Neyaz, Dale R. Gardner, Rebecca Creamer, Daniel Cook   +3 more
doaj   +1 more source

Silencing of the Transmembrane Transporter (swnT) Gene of the Fungus Slafractonia leguminicola Results in a Reduction of Mycotoxin Transport

Journal of Fungi, 2023
Slafractonia leguminicola infects red clover and other legumes, causing black patch disease. This pathogenic fungus also produces two mycotoxins, slaframine and swainsonine, that are toxic to livestock grazing on clover hay or pasture infested with S ...
Sumanjari Das, Dale R. Gardner, Marwa Neyaz, Allen B. Charleston, Daniel Cook, Rebecca Creamer   +5 more
doaj   +1 more source

Asymmetric Synthesis of (−)-Swainsonine, (+)-1,2-Di-epi-swainsonine, and (+)-1,2,8-Tri-epi-swainsonine

, 2016
The asymmetric synthesis of (−)-swainsonine via a nonchiral pool route that involves the Sharpless epoxidation to induce chirality is reported. The key steps involve vinyl epoxide aminolysis, ring-closing metathesis, and intramolecular N-alkylation to ...
Karl B. Lindsay (2278303), Stephen G. Pyne (1403101)   +1 more
core   +1 more source

Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells

Frontiers in Pharmacology, 2021
Swainsonine (SW), an indolizidine alkaloid extracted from locoweeds, was shown toxic effects in multiple studies, but the underlying action mechanism remains unclear.
Shuai Wang, Shuai Wang, Yazhou Guo, Yazhou Guo, Chen Yang, Chen Yang, Ruijie Huang, Ruijie Huang, Yuting Wen, Yuting Wen, Chunyan Zhang, Chunyan Zhang, Chenchen Wu, Chenchen Wu, Baoyu Zhao, Baoyu Zhao   +15 more
doaj   +1 more source