Results 21 to 30 of about 1,931 (193)

Biosynthesis of the α-D-mannosidase inhibitor (-)-Swainsonine. [PDF]

Nat Chem Biol
(-)-Swainsonine is a polyhydroxylated indolizidine alkaloid with potent inhibitory activity against α-D-mannosidases. Although the genetic basis of its biosynthesis has been established, the biosynthetic mechanism underlying its formation remains poorly understood.
Liu S, Batool Z, Hai Y.
europepmc   +3 more sources

Synthesis of the naringinase inhibitors l-swainsonine and related 6-C-methyl-l-swainsonine analogues: (6R)-C-methyl-l-swainsonine is a more potent inhibitor of l-rhamnosidase by an order of magnitude than l-swainsonine

Tetrahedron Letters, 2008
Abstract Efficient syntheses are reported of the α- l -rhamnosidase inhibitors l -swainsonine [(1 R ,2 S ,8 S ,8a S )-octahydroindolizine-1,2,8-triol], (6 R )- C -methyl- l -swainsonine (1 R ,2 S ,6 R ,8 S ,8a S )-6-methyloctahydro-indolizine-1,2,8-triol, (6 S )- C -methyl- l -swainsonine (1 R ,2 S ,6 S ,8 S ,8a S )-6-methyloctahydro-indolizine-1,2 ...
Hakansson, A, van Ameijde, J, Horne, G, Nash, R, Wormald, M, Kato, A, Besra, G, Gurcha, S, Fleet, G   +8 more
openaire   +3 more sources

Phytochemistry, Bioactivity, and Toxicological Duality of Oxytropis glabra DC: A Review [PDF]

Molecules
Oxytropis glabra DC, a Fabaceae species distributed across Central Asia, is characterized by a dual biological profile encompassing pronounced toxicity alongside promising pharmacological potential.
Karlygash Raganina, Akerke Amirkhanova, Sholpan Akhelova, Aiman Berdgaleyeva, Meruyert Amantayeva, Elmira Kartbayeva, Aigul Kaldybayeva, Madi Nurlybayev, Yerbol Ikhsanov, Nurzhan Iztileu, Zhanserik Shynykul, Moldir Koilybayeva   +11 more
doaj   +2 more sources

Comparative analysis of the gut microbiome of ungulate species from Qinghai-Xizang plateau. [PDF]

Ecol Evol
This study investigated the relationship between the gut bacterial community and the phylogeny of five wild ungulates (Pseudois nayaur, Pantholops hodgsonii, Gazella subgutturosa, Bos mutus, and Equus kiang) inhabiting the Qinghai‐Tibetan Plateau using 16S rRNA gene data.
Wang X, Gao X, Chen Y, Wu X, Shang Y, Zhang Z, Zhou S, Zhang H.   +7 more
europepmc   +2 more sources

Detection of swainsonine and calystegines in Convolvulaceae species from the semiarid region of Pernambuco

Pesquisa Veterinária Brasileira
: Numerous plant species worldwide including some Ipomoea (Convolvulaceae) and Sida (Malvaceae) species in Brazil cause lysosomal storage disease in herbivores and are known to contain swainsonine and calystegines as the main toxic compounds.
Fábio S. Mendonça, Givaldo B. Silva Filho, Hisadora A.S. Chaves, Lorena D.A. Aires, Thaiza C. Braga, Dale R. Gardner, Daniel Cook, Maria T. Buril   +7 more
doaj   +2 more sources

Transcriptomic Screening of Alternaria oxytropis Isolated from Locoweed Plants for Genes Involved in Mycotoxin Swaisonine Production [PDF]

Journal of Fungi
Locoweed is a collective name for a variety of plants, such as Oxytropis and Astragalus L. When these plants are infected by some fungi or endophytes, they will produce an alkaloid (swainsonine) that is harmful to livestock.
Shuangjie Yuan, Qingmei Zhao, Kun Yu, Ying Gao, Zhengbing Ma, Huanyu Li, Yongtao Yu   +6 more
doaj   +2 more sources

Swainsonine affects the processing of glycoproteins in vivo

FEBS Letters, 1983
Rats, sheep and guinea pigs treated with swainsonine excrete ‘high mannose’ oligosaccharides in urine. The major rat and guinea pig oligosaccharide is (Man)5GlcNAc whereas sheep excrete a mixture of oligosaccharides of composition (Man)2–5GlcNAc2 and (Man)3–5GlcNAc.
Abraham, D.J., Sidebothom, R., Winchester, B.G., Dorling, P.R., Dell, A.   +4 more
openaire   +3 more sources

Host-Species Variation and Environment Influence Endophyte Symbiosis and Mycotoxin Levels in Chinese Oxytropis Species

Toxins, 2022
Oxytropis plants are widely distributed in the grasslands in northern China. Some Oxytropis species have been reported to contain the mycotoxin swainsonine, an alkaloid which causes poisoning in livestock, referred to as locoism.
Chenchen Guo, Li Zhang, Qianqian Zhao, Manfred Beckmann, Helen Phillips, Huizhen Meng, Chonghui Mo, Luis A. J. Mur, Wei He   +8 more
doaj   +1 more source

Acquisition of drug resistance and dependence by prions. [PDF]

PLoS Pathogens, 2013
We have reported that properties of prion strains may change when propagated in different environments. For example, when swainsonine-sensitive 22L prions were propagated in PK1 cells in the presence of swainsonine, drug-resistant variants emerged.
Anja M Oelschlegel, Charles Weissmann
doaj   +1 more source

Golgi a-mannosidase II mediates the formation of vascular smooth muscle foam cells under inflammatory stress

Folia Histochemica et Cytobiologica, 2021
INTRODUCTION: Vascular smooth muscle cells (VSMCs)-based foam cell formation is a crucial factor in the atherosclerosis process. We aimed to explore the mechanism of Golgi a-mannosidase II (GMII) effects on the VSMCs-based foam cell formation.
Kelan Zha, Qiang Ye
doaj   +1 more source