Results 61 to 70 of about 1,931 (193)
Journal of Fungi, 2021 The legume Oxytropis sericea hosts a fungal endophyte, Alternaria oxytropis, which produces secondary metabolites (SM), including the toxin swainsonine.
Rebecca Creamer +5 more
doaj +1 more source
The Journal of Antibiotics, 1985 Swainsonine isolated from Metarhizium sp., was found to enhance the activities of the mouse immune system in vitro. Concanavalin A stimulated lymphocyte proliferation and proliferative response in mixed lymphocytes culture, which were suppressed by immunosuppressive factor obtained from serum of sarcoma 180 tumor bearing mouse, were restored to normal ...
M, Hino +8 more
openaire +3 more sources
, 2016 5α-Substituted swainsonine analogues were synthesized by Mannich reaction of an in situ generated (−)-swainsonine iminium ion intermediate.
Yoshihiro Uto (2723560) +5 more
core +2 more sources
A convenient approach to (-)-8-epi-swainsonine
, 2006 A novel and efficient synthesis of (-)-8-epi-swainsonine (2) is reported. Face-selective diol formation from the bicyclic alkene 3 followed by a stereoselective vinylation of the aldehyde and ring-closing metathesis gave the indolizidine ring system ...
Adrian J Murray (16063691) +1 more
core +1 more source
Ecotoxicology and Environmental SafetyLong-term consumption of swainsonine could be poisonous to livestock, including facilitating apoptosis by impairing lysosomal function and inhibiting autophagic degradation, leading to liver inflammation and even death in livestock.
Ling Lei +6 more
doaj +1 more source
Swainsonine: an inhibitor of glycoprotein processing. [PDF]
Proceedings of the National Academy of Sciences, 1981 Swainsonine, an indolizidine alkaloid, inhibits the processing of asparagine-linked glycoproteins in both cell-free extracts and animal cells in culture. Thus, in a liver particulate enzyme preparation, swainsonine at 0.1-1.0 microM inhibited the mannosidase that releases [3H]mannose from a high mannose glycopeptide but only slightly inhibited the ...
A D, Elbein +3 more
openaire +2 more sources
Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
A survey of swainsonine content in Swainsona species
, 2017 The indolizidine alkaloid swainsonine is an inhibitor of α-mannosidase and mannosidase II that causes lysosomal storage disease and alters glycoprotein processing.
Daniel Cook +3 more
core +1 more source
Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death
Cancer Science, Volume 116, Issue 5, Page 1181-1192, May 2025.This review provides a thorough examination of contemporary studies on cytoplasmic vacuolization in mammalian cells, elucidating its etiology, origins, and molecular pathways. Additionally, it highlights the potential of CVACD as an innovative therapeutic strategy for cancer.
Xiaoxu Wen, Hongru Ma
wiley +1 more source
Potential Degradation of Swainsonine by Intracellular Enzymes of Arthrobacter sp. HW08
Toxins, 2013 Swainsonine (SW) is a toxin produced by locoweeds and harmful to the livestock industry. Degrading SW by Arthrobacter sp. HW08 was demonstrated as a promising way to deal with SW poisoning.
Haili Li +7 more
doaj +1 more source