Results 81 to 90 of about 1,931 (193)
Toxic Plants and Their Impact on Livestock Health and Economic Losses: A Comprehensive Review
Journal of Toxicology, Volume 2024, Issue 1, 2024.Plants are important components in sustaining the life of humans and animals, balancing ecosystems, providing animal feed and edible food for human consumption, and serving as sources of traditional and modern medicine. However, plants can be harmful to both animals and humans when ingested, leading to poisoning regardless of the quantity consumed ...
Tagesu Abdisa +2 more
wiley +1 more source
Synthesis of (-)-swainsonine and (-)-8-epi-swainsonine from (S)- and (R)-glutamic acid derivatives.
Chemical and Pharmaceutical Bulletin, 1990 (-)-Swainsonine (1) and (-)-8-epi-swainsonine were synthesized from (S)- and (R)-glutamic acid derivatives. (2R, 3S, 4R)-3, 4-Dihydroxy-2-hydroxymethylpyrolidine derivatives (9a and 9b) were prepared by cis-dihydroxylation of α, β-unsaturated compounds 6, 10 and 15 with OsO4 as the key reaction.
IKOTA, Nobuo, HANAKI, Akira
openaire +2 more sources
A Formal Synthesis of Swainsonine by Gold-Catalyzed Allene Cyclization
, 2016 A formal synthesis of swainsonine has been achieved using a highly efficient and diastereoselective gold(III)-catalyzed allene ...
Roderick W. Bates (2175544) +1 more
core +2 more sources
Molecular Cancer, 2007 Background Drug resistance is a major problem in cancer chemotherapy. Acquisition of chemo-resistance not only reduces the effectiveness of drugs, but also promotes side effects and markedly reduces the patient's quality of life.
Sato Yuji +10 more
doaj +1 more source
Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype of Gastric Carcinomas
Molecules, 2018 Cellular glycosylation plays a pivotal role in several molecular mechanisms controlling cell–cell recognition, communication, and adhesion. Thus, aberrant glycosylation has a major impact on the acquisition of malignant features in the tumor progression ...
Meritxell Balmaña +5 more
doaj +1 more source
, 2007 A novel and efficient synthesis of (-)-8-epi-swainsonine 2 is reported. Stereocontrolled diol formation from the bicyclic alkene 3 followed by a stereoselective vinylation of the aldehyde and ring closing metathesis gave the indolizidine ring system ...
Adrian J Murray (16063691) +2 more
core
Spontaneous poisoning by Sida carpinifolia (Malvaceae) in horses
Pesquisa Veterinária Brasileira: Sida carpinifolia poisoning causes a chronic neurodegenerative disorder associated with lysosomal storage by indolizidine alkaloids (swainsonine). The epidemiological, clinical, pathological and lectin histochemistry findings of an outbreak of natural ...
Daniele M. Bassuino +5 more
doaj +1 more source
, 2006 Chiral α-hydroxy-aldehydes generated in situ by the ADH reaction of vinyl sulfones undergo a borono-Mannich reaction with β-styrenyl boronic acid and primary amines to give anti-1,2-amino alcohols in high enantiomeric purities (ee 83-95%).
Christopher Au (20116887) +1 more
core
3-D structure of SpGH38 and its swainsonine complex.
, 2013 (A) 3-D topology cartoon (divergent stereo) colored according to domains with swainsonine in ball-and-stick. N-term (red: 1–294) 3-α (green: 295–392), β-1 (blue: 393–514,806–825), β−2 (yellow: 522–805) and β−3 (cyan: 825–901) (B) Surface representation ...
Julia Walton (367306) +6 more
core +1 more source
, 2023 Swainsonine induced liver inflammation in livestock; however, the underlying mechanisms, especially the role of bile acids (BAs), in the pathogenesis remained elusive. Here, our results showed that swainsonine induced hepatic inflammation via changing BA
Xuefeng Yuan +19 more
core +1 more source