Results 91 to 100 of about 1,931 (193)

Synthesis of Tetrahydroxyquinolizidines:  Ring-Expanded Analogs of the Mannosidase Inhibitor Swainsonine

, 2016
The indolizidine azasugar swainsonine (1) is an important inhibitor of mannosidase II and has shown antitumor and immunomodulatory activity. A comparison of the structure of swainsonine and d-mannopyranose shows that swainsonine lacks the C(4 ...
Erik J. Hembre (3008280), William H. Pearson (2490808)   +1 more
core   +2 more sources

Secretion of rat hepatic lipase is blocked by inhibition of oligosaccharide processing at the stage of glucosidase I

Journal of Lipid Research, 1990
Rat hepatic lipase is a glycoprotein bearing two N-linked oligosaccharide chains. The importance of glycosylation in the secretion of hepatic lipase was studied using freshly isolated rat hepatocytes.
AJ Verhoeven, H Jansen
doaj   +1 more source

De Novo Asymmetric Synthesis of d- and l-Swainsonine

, 2016
The enantioselective syntheses of both enantiomers of the indolizidine natural product swainsonine have been achieved in 13 steps from furan. The indolizidine ring system is installed by a one-pot hydrogenolysis of both an azide and an O-Bn group along ...
Haibing Guo (2340589), George A. O'Doherty (2238649)   +1 more
core   +1 more source

Studies toward New Anti-Cancer Strategies Based on ?-Mannosidase Inhibition

CHIMIA, 2010
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression.
Sandrine Gerber-Lemaire, Lucienne Juillerat-Jeanneret   +1 more
doaj   +1 more source

Ipomoea brasiliana poisoning on buck reproduction

Ciência Rural, 2018
: Swainsonine-containing plants comprise a group of important poisonous plants in Brazil. This research aimed to characterize both the behavioral changes related to reproduction and appearance of lesions in the reproductive system of bucks poisoned by ...
Ana Lizia Brito da Cunha, Juliana Pinto de Medeiros, Franklin Riet-Correa, Dale Gardner, Hisadora Advíncula da Silva Chaves, Givaldo Bom da Silva Filho, Francisco de Assis Leite Souza, Joaquim Evêncio Neto, Fábio de Souza Mendonça   +8 more
doaj   +1 more source

Immunomodulatory effects of swainsonine from Ipomoea carnea in healthy mice

, 2009
The objective of this study was to more clearly characterize the immunomodulatory effects of swainsonine and an Ipomoea carnea aqueous fraction using two different mouse strains: Swiss outbred mice and C57BL/6 inbred mice.
HARAGUCHI, Mitsue, MARIANO-SOUZA, Domenica Palomaris, HUEZA, Isis Machado, LATORRE, Andréia Oliveira   +3 more
core  

Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population.

PLoS ONE, 2019
Cervical cancer, caused by high oncogenic risk Human Papillomavirus (HPV) infection, continues to be a public health problem, mainly in developing countries.
Caio Raony Farina Silveira, Marcella Cipelli, Carolina Manzine, Silvia Helena Rabelo-Santos, Luiz Carlos Zeferino, Gretel Rodríguez Rodríguez, Josiane Betim de Assis, Suellen Hebster, Isabel Bernadinelli, Fabio Laginha, Enrique Boccardo, Luisa Lina Villa, Lara Termini, Ana Paula Lepique   +13 more
doaj   +1 more source

ENANTIOSPECIFIC SYNTHESIS OF SWAINSONINE, (1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE, FROM D-MANNOSE

, 1984
An enantiospecific synthesis of swainsonine from D-mannose is described; the heterocyclic rings of swainsonine are constructed by two intramolecular reductive aminations caused by the catalytic hydrogenation of an azidoaldehyde with 5 equivalents of ...
M.J. Gough, FLEET, G, G.W.J. Fleet, P.W. Smith, SMITH, P, GOUGH, M   +5 more
core   +1 more source

Hypomyelinogenesis associated with transplacental poisoning by Sida carpinifolia (Malvaceae) in fetus and newborn calves

Pesquisa Veterinária Brasileira
: Sida carpinifolia is a plant responsible for poisoning several species of animals. This paper describes Hypomyelinogenesis in fetuses and neonates of cattle that consumed S. carpinifolia. Neonates manifested ataxia and muscle tremors.
Matheus O. Reis, Raquel A.S. Cruz, Daniele M. Bassuino, Fabiana M. Boabaid, Luiz Gustavo S. Oliveira, Lauren S. Mello, Luciana Sonne, David Driemeier   +7 more
doaj   +1 more source

Effects of the alpha-mannosidase inhibitors, 1,4-dideoxy-1,4-imino-D-mannitol and swainsonine, on glycoprotein catabolism in cultured macrophages.

, 1989
Thioglycollate-stimulated murine peritoneal macrophages were cultured for eight days in the presence of swainsonine, or 1,4-dideoxy-1,4-imino-D-mannitol (DIM), or both of these competitive alpha-mannosidase inhibitors together.
Smith, PW, Daniel, PF, O'Neil, NE, Newburg, DS, Fleet, GW   +4 more
core   +1 more source