Results 91 to 100 of about 409,184 (262)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Mirrors in Russian Decadent and Symbolist Prose: Valery Briusov and Dmitry Merezhkovsky

open access: yesStudies in 20th & 21st Century Literature, 2010
Examining mirror imagery in the prose works “In the Mirror” by Valery Briusov and The Resurrected Gods: Leonardo da Vinci by Dmitry Merezhkovsky, both published in 1902, this article situates the Russian Decadent and Symbolist associations of the ...
Kirsten Lodge
doaj   +1 more source

The Emily Davison Lodge - "Out of the Archives" [PDF]

open access: yes
A series of commissioned artworks (4) made with Olivia Plender in response to materials in the Women's Library, specifically recovering and re-historicising the suffragette as a militant artist and with a particular emphasis on collating existing records
Plender, Olivia, Reeve, Hester
core  

The Whalesong [PDF]

open access: yes, 2003
Academic opportunities for summer and fall -- Self-proclaimed Baghdad mayor prepares for office amid skepticism by city residents -- Everyone's an alcoholic according to AUDIT -- Impeach Bush: I don't think so -- Sad loss at Housing Lodge -- Letters to ...

core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

[Review of] Raymond A. Bucko. The Lakota Ritual of the Sweat Lodge [PDF]

open access: yes, 1998
This well-researched book presents an excellent anthropological discussion of the ritual aspects of the sweat lodge as practiced among some Lakota, while posing some very thorny problems in terms of treatment of religion, knowledge and spirituality ...
Fenelon, James V.
core   +1 more source

The effectiveness of Neuro-Linguistic Programming (NLP) on students’ motivation and attitude [PDF]

open access: yes, 2020
Neuro-Linguistic Programming (NLP) was developed at the University of California at Santa Cruz in the 1970's by its founders and principal authors, Richard Bandler and John Grinder, a professor of linguistics (Tosey & Mathison, 2003). Richard Bandler was
Abdul Hamid, Ahmad Faqirudin   +2 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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