Results 111 to 120 of about 28,496 (267)

Beavers on Ice: Factors Influencing Emergence Phenology in Boreal Canada. [PDF]

Glob Chang Biol
Hood GA, Patriquin DLD.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Return of the Megaureter: A Sequel no One Expected an Enigmatic Case of Ureteral Stump Syndrome. [PDF]

Clin Case Rep
Filippini V, Cochetti G, Quaranta A, Mearini M, Valitutti F.   +4 more
europepmc   +1 more source

Effect of Lodging on Seed Yield of Field-Grown Soybean -Artificial Lodging and Lodging Preventing Treatments-

Japanese Journal of Crop Science, 2012
Saitoh, Kuniyuki, Nishimura, Kuniko, Kitahara, Toshinobu   +2 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Cervical lymph node metastasis from occult tonsillar squamous cell carcinoma with incidental ectopic parathyroid tissue: a case report. [PDF]

J Surg Case Rep
Izzo P, De Intinis C, Lai S, D'Urso A, Sibio S, Meloni P, Di Cello P, Izzo L, Molle M, Izzo S.   +9 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Navigating the Aortopathy Dilemma in Pregnancy: Case Series Insights From a Cardiac Surgical Center. [PDF]

JACC Case Rep
Fairley SL, Tromop-van Dalen C, Kirby A, Aitken A, Lodge JS, Gunderson S, Bowden V, Galvin S, Cheung A, Ferrier K.   +9 more
europepmc   +1 more source