Results 111 to 120 of about 434,695 (312)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Ecology and EvolutionObtaining measures of population size and fitness are key first steps to understanding how and why species' populations change over time. Quantifying such metrics is difficult in some species, however, due to their remote location and/or ecology, that is
Sophie Bennett +8 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Phillip DeVito Honors and Awards: Oregon Winegrower\u27s Association [PDF]
, 1993 The Oregon Winegrower\u27s Association Outstanding Service Award was given to Phillip DeVito in 1993. The certificate reads, For outstanding service to Oregon\u27s Vineyards and Wineries. As part of a long career in the Oregon wine industry, DeVito was
DeVito, Phillip
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Pelayanan Rawat Inap Puskesmas Sungai Pakning Kec.bukit Batu Kab. Bengkalis [PDF]
, 2014 Service Take Care Of To Lodge Puskesmas Sungai Pakning Kec. Bukit Batu Kab. Bengkalis. This study aimed to know Take Care To Lodge sevice at Puskesmas Sungai Pakning, and to know factors resistor of execution of service at puskesmas sungai pakning ...
KHAIRANI, T. (TUTI), Sabela, R. (Robi)
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
, 1987 UAJ Library links-up to new computer system -- Student store to go in at the Housing Lodge -- Retain marketing, recruitment development at UAJ at all costs -- Jury still out on UAJ Music Dept. Funding -- Support new G.I.
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source