Results 141 to 150 of about 61,463 (315)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

[Lodge Summons from Free and Accepted Masons, Lodge No. 441]

open access: yes, 1923
A Masonic lodge summons.Date based on Freemason's calendar system which adds 4000 years to current year. [5923 - 4000 = 1923]. Recto: [imprinted] Lodge Summons.[descriptive text not transcribed]
Freemasons. Garland Masonic Lodge, No. 441 (Garland, Tx.)
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PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Proceedings of the right worthy Grand Lodge of the State of Wisconsin at its ... annual session.

open access: yes
Held at various places.At head of title: I.O.O.F.Title varies slightly.Includes report for semi-annual session: 1852.Mode of access ...
Independent Order of Odd Fellows. Grand Lodge of Wisconsin.
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Groundhog Lodge #1 2001

open access: yes, 2001
The events at Groundhog Lodge #1 in 2001. These meetings are in the Pennsylvania German Deitsch language and are important heritage events.
Lodge #1, Groundhog
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Lodge, Wallace. Interview about growing up and living in Port Union.

open access: yes, 1998
Transcript and digitized audio recording from a collection belonging to the Sir William F. Coaker Heritage Foundation.
Sir William F. Coaker Heritage Foundation; Joy, Margaret
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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

[Letter] 1915 September 21, Mariemont, Edgbaston [to] Sadler / Oliver Lodge.

open access: yes, 1915
The letter is written on letterhead for Mariemont, Edgbaston which is in Birmingham, England where Lodge was associated with the university.Lodge thanks Sadler for writing and enquires whether Bragg has lost his son, saying he hesitates to write to him ...

core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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