Results 51 to 60 of about 67,630 (295)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Circular 21 [PDF]

, 1955
Developed from the hybrid Diamond x Khogot by the Alaska Agricultural Experiment Station, Gasser wheat was released to seed producers in 1955. This variety exhibits an excellent combination of high yield and agronomic desirability m Alaska.
Brinsmade, J.C., Taylor, R.L.
core  

The relationships between maize (Zea mays L.) lodging resistance and yield formation depend on dry matter allocation to ear and stem

Crop Journal, 2023
Lodging is a critical constraint to yield increase. There appear to be tradeoffs between yield formation and lodging resistance in maize. Hypothetically, it is feasible to reduce lodging risk as well as increase grain yield by optimizing dry-matter ...
Ping Zhang, Shuangcheng Gu, Yuanyuan Wang, Chenchen Xu, Yating Zhao, Xiaoli Liu, Pu Wang, Shoubing Huang   +7 more
doaj   +1 more source

Thickness-stiffness trade-off improves lodging resistance in rice

Scientific Reports, 2023
AbstractLodging of cereal crops significantly reduces grain yield and quality, making lodging resistance a prime target for breeding programs. However, lodging resistance among different rice (Oryza sativa L.) cultivars in the field remains largely unknown, as is the relationship between the major properties of culms such as their morphological and ...
Satoru Tsugawa, Hiroyuki Shima, Yukitaka Ishimoto, Kazuya Ishikawa   +3 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dissecting the Phenotypic Regulation Characteristics of Lodging Resistance in Dry Direct Seeding Rice: Insights from Stem Mechanics and Structural Traits

Plants
Lodging is a major constraint limiting grain yield in dry direct seeding rice (DDSR), yet the key traits and phenotypic relationships governing lodging resistance in japonica varieties adapted to this system remain poorly understood. This study evaluated
Zhiqiang Tang, Chao Liang, Li Wen, Wurina Sun, Jicong Liu, Zuobin Ma, Wenjing Zheng, Shu Wang, Hui Wang   +8 more
doaj   +1 more source

Understanding of crop lodging and agronomic strategies to improve the resilience of rapeseed production to climate change

Crop and Environment, 2022
Crop lodging has long been recognized as one of the severe yield limiting constraints for rapeseed (Brassica napus) production worldwide. Lodging directly impairs seed yield and quality by interfering with photosynthesis, dry matter accumulation and ...
Wei Wu, Farooq Shah, Bao–Luo Ma
doaj   +1 more source

Eräiden kevätviljalajikkeiden laonkestävyystekijöistä [PDF]

, 2002
vokKirjasto Aj-kOn the factors affecting resistance to lodging in some varieties of spring ...
Multamäki, K
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source