Results 61 to 70 of about 128,243 (298)

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Apparent timing and duration of the Matuyama-Brunhes geomagnetic reversal in Chinese loess [PDF]

, 2014
       The Matuyama-Brunhes (MB) geomagnetic reversal in Chinese loess has been studied extensively as an important boundary for land-ocean stratigraphic and paleoclimatic correlations.
An, An, An, Berger, Bleil, Bloemendal, Burbank, Channell, Channell, Channell, Channell, Clemens, deMenocal, Ding, Ding, Ding, Ding, Ding, Ding, Ding, Glatzmaier, Guo, Guo, Hao, Hao, Helalia, Heller, Heslop, Horng, Hui Zhao, Hyodo, Hyodo, Imbrie, Jacobs, Jin, Jin, Jin, Kukla, Kukla, Kukla, Lisiecki, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Lu, Meeril, Oda, Okada, Porter, Qiang, Rutter, Rutter, Spassov, Spassov, Suganuma, Suganuma, Sun, Sun, Sun, Sun, Sun, Sun, Sun, Sun, Tauxe, Vandenberghe, Wang, Wang, Wang, Wang, Xiao, Xiaoke Qiang, Yamazaki, Yang, Yang, Yang, Yang, Youbin Sun, Yu, Zhao, Zhou, Zhou, Zhu, Zhu, Zhu, Zhu   +89 more
core   +1 more source

Pharmacokinetic‐pharmacodynamic modelling of risankizumab using chronic plaque psoriasis real‐world data

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Risankizumab is a high‐cost biologic treatment for chronic plaque psoriasis, an immune‐mediated inflammatory disease presenting with painful red scaly skin lesions. Inter‐individual heterogeneity in treatment response may be better addressed with personalised rather than fixed dosing. We sought to develop a pharmacokinetic/pharmacodynamic (
Charlotte M. Thomas, Jessica Ruoheng Wei, David Baudry, Zehra Arkir, Bola Coker, Tejus Dasandi, Kingsley Powell, Monica Arenas‐Hernandez, Jenny Leung, Krystal Rawstron, Chioma Nwaogu, Richard Woolf, Andrew E. Pink, Jonathan Barker, Joseph F. Standing, Catherine H. Smith, Satveer K. Mahil   +16 more
wiley   +1 more source

Single Aliquot Regeneration (SAR) Optically Stimulated Luminescence Dating Protocols Using Different Grain-Sizes of Quartz: Revisiting the Chronology of Mircea Vodă Loess-Paleosol Master Section (Romania)

Methods and Protocols, 2020
The loess-paleosol archive from Mircea Vodă (Romania) represents one of the most studied sections in Europe. We are applying here the current state of the art luminescence dating protocols for revisiting the chronology of this section.
Ștefana-M. Groza-Săcaciu, Cristian Panaiotu, Alida Timar-Gabor   +2 more
doaj   +1 more source

Renaturierung kleiner Lössbäche – ein Beitrag der Ökologischen Landwirtschaft zum Naturschutz [PDF]

, 2013
As a part of the interdisciplinary research project ”Integration of nature protection goals with organic farming: an the example from the Hessian ”state domain” [Staatsdomäne] area Frankenhausen”, different restoration measures have been carried out ...
Braukmann, Ulrich, Haaß, Werner, Rupp, Bastian, Schütte, Achim, Stein, Ulf   +4 more
core  

Potential of a digital parenting app to support parents of toddlers: Relations between the intensity of app use, language‐related parental self‐efficacy and the home literacy environment

British Educational Research Journal, EarlyView.
Abstract The home literacy environment (HLE) has a considerable influence on children's language development. How parents perceive their own parenting abilities (e.g., how well they encourage their children's language development) is particularly important when it comes to guiding their children appropriately through different stages of development ...
Luisa Prokupek, Theresia Hummel, Sabine Blaurock, Franziska Cohen, Yvonne Anders   +4 more
wiley   +1 more source

Dynamics of loess mass deformations due to technogenic load [PDF]

, 2014
По результатам анализа энергетических и фильтрационных свойств техногенно нагруженного лессового массива определен интервал глубин, и геологические слои, характеризующиеся наиболее интенсивным развитием деформационных и суффозионных процессов ...
Derevyagina, N. I., Podvigina, E. O., Sadovenko, I. A., Zagricenko, A. N., Деревягина, Наталия Ивановна, Загриценко, Алина Николаевна, Подвигина, Елена Олеговна, Садовенко, Іван Олександрович   +7 more
core  

Lower Dose‐Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss‐of‐Function Allele Carriers: A Longitudinal Retrospective Real‐World Study in Kidney Transplant Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non‐European populations. This bias is exemplified by CYP3A5*6, a functionally consequential variant common in individuals of African ancestry (MAF: 11–19%) but virtually absent in Europeans (MAF: 0.15%)
Amar D. Levens, Dirk Jan A. R. Moes, Yanick Boer, Aiko P. J. de Vries, Dorottya K. de Vries, Danny van der Helm, Soufian Meziyerh, Dave L. Roelen, Stefan Böhringer, Teun Van Gelder, Jesse J. Swen   +10 more
wiley   +1 more source

MISCANTHUS CULTIVATION IN ROCKS WITH DIFFERENT GEOLOGICAL AGE [PDF]

, 2018
Recently, more and more scientists give to Miscanthus the leading part on supplying cellulose-rich feedstock for energy production and the chemical industry.
Babenko, Mykhaylo, Gumentyk, Mykhaylo, Katelevsky, Valery, Kharytonov, Mykola, Martynova, Nadiia   +4 more
core  

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source