Results 121 to 130 of about 34,114 (259)
Cancer Science, EarlyView.Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai +10 more
wiley +1 more source
Libro: Küme mongen en el lof Temulemu. Diagnóstico de salud. Conclusiones y propuestas, 2023
The diagnosis of lof Temulemu aims to provide an overview of the situation of the Küme mongen, good life or well-being from the perspective of the Mapuche families that comprise it.
Plan de Salud Integral Indígena PRI Lonco, Lof Temulemu y Servicio Salud Araucanía Norte, Ministerio de Salud, Gobierno de Chile
core +1 more source
Child &Family Social Work, EarlyView.ABSTRACT Digital transformations increasingly shape children's everyday lives, positioning parents as key mediators of digital risk, opportunity and trust within the family context. In early childhood, where children cannot independently regulate digital environments, parental media practices are critical for fostering digital resilience and risk ...
Serpil Çelikten Demirel +3 more
wiley +1 more source
A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy
Clinical Genetics, EarlyView.PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady +3 more
wiley +1 more source
Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease
Clinical Genetics, EarlyView.Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler +5 more
wiley +1 more source
Clinical Genetics, EarlyView.Heterozygous de novo nonsense variants in the penultimate and last exons of NUSAP1 were identified in two unrelated individuals, predicted to escape NMD. In population data, nonsense variants were observed in exons 1–9 (of 11) in NUSAP1 but were absent from its 3′‐terminal region.
Maureen Jacob +15 more
wiley +1 more source
Institutional lessons from the Nordic management model
Conservation Biology, EarlyView.Abstract To improve wildlife management outcomes, in terms of reaching management goals and increasing legitimacy, Nordic countries have developed institutional systems involving stakeholders that aim for a more inclusive and participatory model.
Jens Nilsson +2 more
wiley +1 more source
, 2015 Openbare les lectoraat Publieke Zorg en Preventie voor Jeugd. Het lectoraat maakt deel uit van het Kenniscentrum Zorginnovatie van Hogeschool Rotterdam. De missie van het lectoraat is om een bijdrage te leveren aan effectieve preventie van psychosociale problemen van jeugdigen.
openaire
Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells
Cell Proliferation, EarlyView.Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley +1 more source