Results 51 to 60 of about 122,769 (286)

The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance [PDF]

, 2011
The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares ...
Broihier, Heather T, DiAntonio, Aaron, Liu, Nan, Weng, Yi-Lan   +3 more
core   +2 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Management of lethal recessive alleles in beef cattle through the use of mate selection software

Genetics Selection Evolution, 2019
Background Recessive loss-of-function (LOF) alleles at genes which are essential for life, can result in early embryonic mortality. Cattle producers can use the LOF carrier status of individual animals to make selection and mate allocation decisions ...
Lindsay R. Upperman, Brian P. Kinghorn, Michael D. MacNeil, Alison L. Van Eenennaam   +3 more
doaj   +1 more source

Composition and abundance of collembola in primary and logged over forest. [PDF]

, 2010
The composition and abundance of collembola among three different forest habitats of the Sungai Lalang Forest Reserve, Selangor Malaysia were compared.The three forest habitats selected were primary forest,5-year old logged over forest(LOF) and 10-year ...
A.B., Idris, Haneda, Noor Farikhah, Sajap, Ahmad Said   +2 more
core  

Heterogeneity in Stock Pricing : A STAR Model with Multivariate Transition Functions [PDF]

, 2010
Stock prices often diverge from measures of fundamental value, which simple present value models fail to explain. This paper tries to find causes for these long-run price movements and their persistence by estimating a STAR model for the price-earnings ...
Lof, Matthijs
core  

Are subsets necessary in Martin-Lof type theory? [PDF]

, 1992
After introducing Martin-Lof's type theory, the paper introduces the rules proposed by various authors for adding subset types to the system, and the justification given for their addition.
Thompson, Simon
core   +1 more source

A Novel Gain‐of‐Function ITPR1 Variant Associated With a Movement Disorder Characterized by Tremor and Dystonia

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The 1,4,5‐trisphosphate receptor type 1 (ITPR1) gene encodes an endoplasmic reticulum calcium release channel, in which loss‐of‐function mutations have been associated with spinocerebellar ataxias and related neurological phenotypes. Only one gain‐of‐function mutation in the highly conserved suppressor domain of ITPR1 has been previously ...
Emilie T. Théberge, Bo Sun, Ruiwu Wang, Arezoo Mohajeri, Clara D. M. Van Karnebeek, Cornelius F. Boerkoel, Stephanie Huynh, Gabriella Horvath, S. R. Wayne Chen, Anna Lehman   +9 more
wiley   +1 more source

Impact of PCSK9 loss-of-function genotype on 1-year mortality and recurrent infection in sepsis survivorsResearch in context

EBioMedicine, 2018
Background: Reduced activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) has been associated with decreased short-term death in patients with septic shock.
Kelly Roveran Genga, Cody Lo, Mihai S. Cirstea, Fernando Sergio Leitao Filho, Keith R. Walley, James A. Russell, Adam Linder, Gordon A. Francis, John H. Boyd   +8 more
doaj   +1 more source

Hand‐onset weakness is a common feature of ALS patients with a NEK1 loss‐of‐function variant

Annals of Clinical and Translational Neurology, 2020
Objective The NEK1 gene has been recently implicated in amyotrophic lateral sclerosis (ALS). This study aims to assess the influence of NEK1 variants on the occurrence of ALS and investigate the spectrum and clinical features of NEK1 loss‐of‐function ...
Yu‐Shuen Tsai, Kon‐Ping Lin, Kang‐Yang Jih, Pei‐Chien Tsai, Yi‐Chu Liao, Yi‐Chung Lee   +5 more
doaj   +1 more source