Results 31 to 40 of about 487,122 (264)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Logit analysis of genetic data
Mathematical Modelling and Analysis, 2008 A new framework of genetic sequence statistical analysis based on generalized logit model is introduced. Logit analysis is applied to assess the dependence structure (interactions) between DNA nucleotides and to test hypothesis about Markov order of ...
Jurgita Židanavičiutė
doaj +1 more source
Statistica, 2020 The capture-recapture method is widely used by epidemiologists to estimate the size of hidden populations using incomplete and overlapping lists of subjects.
Giuseppe Rossi +3 more
doaj +1 more source
Graphical Local Genetic Algorithm for High-Dimensional Log-Linear Models
Mathematics, 2023 Graphical log-linear models are effective for representing complex structures that emerge from high-dimensional data. It is challenging to fit an appropriate model in the high-dimensional setting and many existing methods rely on a convenient class of ...
Lyndsay Roach, Xin Gao
doaj +1 more source
Annals of Emergency Medicine, 1993 Annals of Emergency Medicine 22 (1993) 1240-1240.
Division of Emergency Medicine University of Florida Health Science Center Jacksonville, USA ( host institution ) +1 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Log-Linear Models for Gene Association [PDF]
Journal of the American Statistical Association, 2009 We describe a class of log-linear models for the detection of interactions in high-dimensional genomic data. This class of models leads to a Bayesian model selection algorithm that can be applied to data that have been reduced to contingency tables using ranks of observations within subjects, and discretization of these ranks within gene/network ...
Hu, Jianhua +2 more
openaire +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source