Results 41 to 50 of about 259,190 (301)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
BarekengThis study compares the Log-linear Realized GARCH (LRG) and its extension with Continuous and Jump components (LRG-CJ) in modeling the volatility of financial assets, using daily data from the Tokyo Stock Price Index (TOPIX) over 2004–2011.
Didit Budi Nugroho +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Finite Dimensional State Representation of Linear and Nonlinear Delay Systems [PDF]
, 2017 We consider the question of when delay systems, which are intrinsically infinite dimensional, can be represented by finite dimensional systems. Specifically, we give conditions for when all the information about the solutions of the delay system can be ...
Metz, J.A.J. +8 more
core +1 more source
LC oscillator frequency prediction using machine learning linear regression algorithm
Discover ElectronicsThe research demonstrates a new method for predicting LC circuit frequencies through linear regression techniques applied to standard resonance formula-derived log-transformed L and C values.
Mandar Jatkar +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Mathematical modeling of triphasic viral dynamics in patients with HBeAg-positive chronic hepatitis B showing response to 24-week clevudine therapy. [PDF]
PLoS ONE, 2012 BACKGROUND: Modeling of short-term viral dynamics of hepatitis B with traditional biphasic model might be insufficient to explain long-term viral dynamics.
Hwi Young Kim +4 more
doaj +1 more source
Analysis of Categorical Data with the R Package confreq
Psych, 2021 The person-centered approach in categorical data analysis is introduced as a complementary approach to the variable-centered approach. The former uses persons, animals, or objects on the basis of their combination of characteristics which can be ...
Jörg-Henrik Heine, Mark Stemmler
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source