Results 41 to 50 of about 1,574,453 (263)

Log-linear modeling

Annals of Emergency Medicine, 1993
Annals of Emergency Medicine 22 (1993) 1240-1240.
Division of Emergency Medicine University of Florida Health Science Center Jacksonville, USA ( host institution ), Wears, Robert L   +1 more
openaire   +2 more sources

Beyond log-linear models [PDF]

Proceedings of the 46th Annual Meeting of the Association for Computational Linguistics on Human Language Technologies Short Papers - HLT '08, 2008
Current re-ranking algorithms for machine translation rely on log-linear models, which have the potential problem of underfitting the training data. We present BoostedMERT, a novel boosting algorithm that uses Minimum Error Rate Training (MERT) as a weak learner and builds a re-ranker far more expressive than log-linear models.
Kevin Duh, Katrin Kirchhoff
openaire   +1 more source

High-dimensional simultaneous inference with the bootstrap

, 2016
We propose a residual and wild bootstrap methodology for individual and simultaneous inference in high-dimensional linear models with possibly non-Gaussian and heteroscedastic errors.
Bühlmann, Peter, Dezeure, Ruben, Zhang, Cun-Hui   +2 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Quantile Estimation Using the Log-Skew-Normal Linear Regression Model with Application to Children’s Weight Data

Mathematics, 2023
In this article, we establish properties that relate quantiles of the log-skew-normal distribution to its parameters, allowing us to investigate the relationship between quantiles of a positive skewed response variable and a set of explanatory variables ...
Raúl Alejandro Morán-Vásquez, Anlly Daniela Giraldo-Melo, Mauricio A. Mazo-Lopera   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Heterogeneity among contingency tables diagnosed by hierarchical log-linear models and their effect on Biplots

Semina: Ciências Exatas e Tecnológicas, 2022
The theory of singular value decomposition of matched matrices is used to verify the heterogeneity of rows, columns and between matched two-way tables.
Carla Regina Guimarães Brighenti, Daniela Aparecida Mafra, Marcelo Angelo Cirillo   +2 more
doaj   +1 more source

Novel Branches of (0,2) Theories

, 2012
We show that recently proposed linear sigma models with torsion can be obtained from unconventional branches of conventional gauge theories. This observation puts models with log interactions on firm footing.
A Adams, A D’Adda, A Strominger, C Quigley, Callum Quigley, CM Hull, D Andriot, D Nemeschansky, D Tong, DR Morrison, DR Morrison, E Witten, FF Gautason, J Gillard, J McOrist, JP Demailly, K Becker, K Becker, K Dasgupta, K Hori, K Hori, K Hori, M Blaszczyk, M Roček, Mark Stern, P Spindel, P Spindel, S Ivanov, Savdeep Sethi, SR Coleman, SR Green   +30 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source