Results 41 to 50 of about 3,443,781 (274)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A conjugate prior for discrete hierarchical log-linear models

, 2009
In Bayesian analysis of multi-way contingency tables, the selection of a prior distribution for either the log-linear parameters or the cell probabilities parameters is a major challenge. In this paper, we define a flexible family of conjugate priors for
Dobra, Adrian, Liu, Jinnan, Massam, Hélène   +2 more
core   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Binary Models for Marginal Independence

, 2007
Log-linear models are a classical tool for the analysis of contingency tables. In particular, the subclass of graphical log-linear models provides a general framework for modelling conditional independences.
Anderson T. W, Anderson T. W., Bergsma W, Bergsma W, Bertsekas D. P, Besag J., Cox D. R., Cox D. R., Dawid A. P., Drton M., Edwards D. M, Ekholm A., Ekholm A., Erdos P., Glonek G. F. V., Hinton G. E., Hojsgaard S, Kauermann G., Kauermann G., Kendler K. S., Kennes R., Knuth D. E, Lauritzen S. L., Levi M., Mao Y., Marchetti G. M., McCullagh P., McCullagh P., Moore A., Pearl J., Pearl J., Putnam R., R Development Core Team, Sztompka P., Wright S.   +34 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

MODEL LOG-LINIER G2 PADA OBSERVASI TRIVARIAT LENGKAP

Jurnal Matematika, 2012
The log-linear models are most used to catagorical data analysis. The catagorical scale is the function transformation value form forth scale measured of observation : nominal, ordinal, ratio and interval. For the data analysis to trivariates observation
I WAYAN SANTIYASA
doaj   +1 more source

Estimation of the growth curve parameters in Macrobrachium rosenbergii [PDF]

, 2011
Growth is one of the most important characteristics of cultured species. The objective of this study was to determine the fitness of linear, log linear, polynomial, exponential and Logistic functions to the growth curves of Macrobrachium rosenbergii ...
Gopal, Krishna, Nagulu, Banoth, Satyanarayana, Y., Srinivasa Rao, P.   +3 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

THE EFFECT OF RETIREMENT ON PERCEIVED WELL-BEING IN HUNGARY

Studia Humanistyczne AGH, 2015
The effect of retirement on perceived well-being is examined by using three waves of the Hungarian GGS data. The marginal log-linear model, which is a useful, state-of-the art methodological tool for categorical multivariate analysis, is applied to the ...
Márta Radó
doaj   +1 more source