Results 101 to 110 of about 356,775 (283)

Factors Affecting Women\'s Birth Intervals: The Case of Women Referred to Health Centers in Ahwaz

حیات, 2015
Background & Aim: Reproductive behavior of a society can be studied in different ways. One of these ways is to check the birth intervals. The aim of the present study was to assess the childbirth along with factors influencing childbirth behavioral ...
Roya Choromzadeh, Mohammad Reza Akhound, Abdolrahman Rasekh   +2 more
doaj   +2 more sources

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

A flexible extension of the log-logistic model with diverse failure rate shapes and applications

Scientific Reports
In this article, we introduce an enhanced version of the log-logistic model, termed the Kumaraswamy alpha-power log-logistic (KAPLL) distribution.
Ahmed Z. Afify, Mohamed E. Mead, Hamada H. Hassan, Abdussalam Aljadani, Abdulaziz S. Alghamdi, Enayat M. Abd Elrazik   +5 more
doaj   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

On fitting and forecasting the log-returns of Bitcoin and Ethereum exchange rates via a new sine-based logistic model and robust regression methods

Alexandria Engineering Journal
Among the different financial sectors, the modeling and forecasting of log-returns of cryptocurrency have received considerable attention. Numerous statistical models have been put forward to analyze the log returns of the cryptocurrency. However, as per
Yiming Zhao, Sultan Salem, Areej M. AL-Zaydi, Jin-Taek Seong, Fatimah M. Alghamdi, M. Yusuf   +5 more
doaj   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Orbitally Stability of Log-Logistic Autoregressive Model with Application

Tikrit Journal of Pure Science
This research aims to study and finding the conditions for stability of the limit cycle of the proposed model (Log-Logistic autoregressive) based on the cumulative function of the Log-Logistic distribution.
Mohammed A. Hamad, Azher A. Mohammad
doaj   +1 more source

Skew Log-logistic distribution: properties and application

Statistics in Transition new series
This paper introduces a novel three-parameter skew-log-logistic distribution. The research involves the development of a new random variable based on Azzalini and Capitanio’s (2013) proposition. Additionally, various statistical properties of this distribution are explored.
Arjun Kumar Gaire, Yogendra Bahadur Gurung   +1 more
openaire   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source