Results 81 to 90 of about 7,988,337 (297)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A best-fit probability distribution for the estimation of rainfall in northern regions of Pakistan

Open Life Sciences, 2016
This study was designed to find the best-fit probability distribution of annual maximum rainfall based on a twenty-four-hour sample in the northern regions of Pakistan using four probability distributions: normal, log-normal, log-Pearson type-III and ...
Amin M. T., Rizwan M., Alazba A. A.
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Log-normal Distribution Type Symmetry Model for Square Contingency Tables with Ordered Categories

Austrian Journal of Statistics, 2018
For the analysis of square contingency tables with the same row and column ordinal classications, this article proposes a new model which indicates that the log-ratios of symmetric cell probabilities are proportional to the difference between log-row ...
Kiyotaka Iki
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Log-normal nanograin-size distributions in nanostructured composites

, 2008
A key challenge in the fabrication of superhard nanocomposite films is how to control the distribution of grain sizes in these materials. High-resolution transmission electron microscopy has been used to measure nanograin-size distributions in the Ti-B-N
Y. Mai (23322769), Y. Shen (2520046), Y. Lu (1469287), Chungsheng Lu (23328997)   +3 more
core  

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

The Log-Rayleigh Distribution for Local Maxima of spectrally Represented Log-normal Processes

We address a novel probability distribution, namely the log-Rayleigh distribution, suited to model the maximum occurring loads in a log-normal process. Log-normal processes in engineering applications can be used to model for example wave or wind loads ...
Bittner, M, Beer, M, Grashorn, J, Wang, C   +3 more
core   +1 more source

Diagnosis plots for the model based on the log-normal distribution (left panel) and the Singh-Maddala distribution (right panel).

, 2020
Diagnosis plots for the model based on the log-normal distribution (left panel) and the Singh-Maddala distribution (right panel).
Thomas Kneib (555150), Maike Hohberg (8452041), Peter Pütz (8452044)   +2 more
core   +1 more source