Results 191 to 200 of about 12,458 (247)
Membrane-Mediated Force Transduction Drives Stick-Slip Motion of Lipid Vesicles. [PDF]
Magrinya P +3 more
europepmc +1 more source
Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose +4 more
wiley +1 more source
Seahorse-Tail-Inspired Soft Pneumatic Actuator: Development and Experimental Characterization. [PDF]
Antonelli MG +3 more
europepmc +1 more source
ABSTRACT The effect of the presence of the BAF‐binding LEM‐domain and LaminA Ig‐fold on the stability of the BAF dimer was studied qualitatively using non‐equilibrium pull simulations and quantitatively through the calculation of the potential of mean force profile along BAF–BAF separation distance.
Aswin Vinod Muthachikavil +2 more
wiley +1 more source
Modeling the Detectability of Energetic Heliospheric Ions at Pluto During the New Horizons Flyby
Abstract We investigate the detectability of heliospheric helium ions at energies up to 100 keV by the New Horizons (NH) spacecraft during its flyby through Pluto's induced magnetosphere. The Pluto Energetic Particle Spectrometer Science Investigation energetic ion detector observed a reduction in their flux by an order of magnitude as the spacecraft ...
Randall T. Ruch +3 more
wiley +1 more source
GmSNAP14: a key contributor to soybean cyst nematode resistance in soybean
Summary Soybean (Glycine max) plants counteract soybean cyst nematode (SCN, Heterodera glycines Ichinohe) infection through an impairment of soluble N‐ethylmaleimide‐sensitive factor (NSF) attachment protein (α‐SNAP) – NSF interactions and vesicular trafficking leading to cellular toxicity in response to nematode feeding.
Vinavi A. Gamage +9 more
wiley +1 more source
Identification and Validation of DLD as a Cuproptosis‐Associated Biomarker in Preeclampsia
DLD is identified as a preeclampsia‐associated cuproptosis hub gene by bioinformatics. DLD overexpression inhibits trophoblast proliferation, invasion, and migration, disrupts TCA cycle metabolism, and alters mitochondrial ultrastructure. These findings reveal that DLD may contribute to preeclampsia pathogenesis through cuproptosis.
Shuisen Zheng +4 more
wiley +1 more source
Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor
Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp +29 more
wiley +1 more source
All-optical processors by 3D printable photochromic materials. [PDF]
D'Elia F +4 more
europepmc +1 more source

