Results 91 to 100 of about 449,073 (289)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Using landscape approaches to improve to improve the integration of wildlife in forest managment plans [PDF]

, 2008
Logging concessions can affect wildlife populations through indirect or direct effects. However, if wildlife is appropriately taken into account in the forest management plans, then logging concessions can become an opportunity for conservation, as they ...
Nasi, Robert, Van Vliet, Nathalie
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Log Evaluation Method and Application of Shale Oil Reservoir in Bongor Basin

Cejing jishu
The evaluation of the main shale oil reservoir in the Baobab block of the Bongor basin, Chad, is insufficient, and a comprehensive method for shale oil resource evaluation is urgently needed.
ZHANG Lihua, QU Peng, HUANG Liang, HOU Qiuyuan, JI Ran, LI Jing   +5 more
doaj   +1 more source

Balloon logging with the inverted skyline [PDF]

, 1975
There is a gap in aerial logging techniques that has to be filled. The need for a simple, safe, sizeable system has to be developed before aerial logging will become effective and accepted in the logging industry.
Mosher, C. F.
core   +1 more source

Harvesting systems for steep terrain in the Italian Alps: state of the art and future prospects [PDF]

, 2016
Steep slope forest operations in Central Europe and in particular in the Alps are strongly related to the adoption of the cable-based harvesting system, even if innovative ground-based harvesting system, even if innovative ground-based harvesting systems
Cavalli, Raffaele, Grigolato, Stefano, Mologni, Omar   +2 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Silviculture in African moist forests : do we have new answers to old questions? [PDF]

, 2011
The silviculture of African tropical moist forests has a long history punctuated with (few) successes and (many) failures. The European foresters in charge of managing forests in the African colonies realized early - e.g. 1900 in Nigeria - that they were
Bertault, Jean-Guy, Billand, Alain, Dupuy, Bernard, Durrieu De Madron, Luc, Fargeot, Christian, Forni, Eric, Gourlet-Fleury, Sylvie, Maître, Henri-Félix, Nasi, Robert   +8 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Research on Key Technology for Perforating 10 000-Metre Deep-Earth Exploration Wells

Cejing jishu
The 10 000-metre deep-earth exploration well shoulders the major tasks of scientific exploration and oil and gas discovery, and has far-reaching significance in the field of ultra-deep oil and gas exploration. In the process of perforating and completing
YU Lei, TANG Kai, CHEN Jianbo, XU Jiale, MA Ziqiang, LI Benchi, LU Yinghui   +6 more
doaj   +1 more source