Results 101 to 110 of about 61,603 (268)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Method for Improving the Evaluation Quality of the Second Cementing Interface Using Acoustic Time Difference Curve

Cejing jishu
Acoustic variable density logging uses the formation wave amplitude received by the 5 ft probe to evaluate the cement bonding quality at the second cementing interface, which is one of the few logging methods that can effectively evaluate the second ...
QIU Enbo, ZHANG Boxin, DAI Yuexiang, DENG Zhaoyuan, CHEN Jing, YANG Xi, TIAN Shiyong, Tonggulike, QI Fei, CHEN Yu, ZHANG Xu, HUANG Haitao   +11 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Research on multi-scale digital core construction of carbonate rock with fractures and caves characteristics: a case study of Dengying formation carbonate rocks in Sichuan Basin

Frontiers in Earth Science
Carbonate reservoirs characterized by fractures and caves exhibit a complex spatial distribution and significant heterogeneity. The establishment of precise and reliable three-dimensional geological models is imperative to elucidate the influence ...
Geli Li, Jianbin Zhao, Yuejiao Liu, Zhanshan Xiao, Shitao Cui, Bo Wei, Chenjun Zhang, Yakun Mao, Yang Xia, Lei Xu, Jianmeng Sun, Zuzhi Hu   +11 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Development and Application of Releasable Cable Head in 10 000 m Ultra Deep Well

Cejing jishu
The exploration and development of ten thousand meter ultra deep oil and gas is a key strategic direction for oilfield companies to search for large oil and gas fields, develop oil and gas storage and increase production in the future. In response to the
ZHANG Haijun, ZHANG Bingjun, SUN Jianwei, MA Jianghu, XU Rui, WANG Kun, GUO Shuai, CHEN Jisheng   +7 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Investigation of Stress Variation in Push-the-Bit Rotary Steering Bearings Under Weight on Bit and Push Forces

Cejing jishu
As the key component of the push-the-bit rotary steerable system, the accuracy and reliability of the bearing system directly affect the control accuracy and drilling efficiency of the drilling tool on the borehole trajectory.
SHEN Bin, YANG Hao, XUE Zhejing, LI Wei, CHENG Feng, LU Lu, WU Jie   +6 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source