Results 121 to 130 of about 449,073 (289)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
NoSEBrEaK - Attacking Honeynets
, 2004 It is usually assumed that Honeynets are hard to detect and that attempts to detect or disable them can be unconditionally monitored. We scrutinize this assumption and demonstrate a method how a host in a honeynet can be completely controlled by an ...
Dornseif, Maximillian +2 more
core +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Tropical managed Forests Observatory: a research network addressing the future of tropical logged forests [PDF]
, 2019 While attention to logging in the tropics has been increasing, studies on the long-term effects of silviculture on forest dynamics and ecology remain scare and spatially limited.
Sist, Plinio
core
Fine-Grain Checkpointing with In-Cache-Line Logging
, 2019 Non-Volatile Memory offers the possibility of implementing high-performance, durable data structures. However, achieving performance comparable to well-designed data structures in non-persistent (transient) memory is difficult, primarily because of the ...
Aksun, David T. +3 more
core +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Typology of logging companies in the Brazilian Amazon [PDF]
, 2011 After 20 years of labeling with a strong increase of certified surfaces all around the world, real advantages and inconveniences of a company certified with regard to a normal company are not well known.
Martinez Plaza, Santiago +2 more
core
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Restoring degraded woodlands [PDF]
, 2009 In many places on the Swan Coastal Plain Eucalyptus gomphocephala (tuart) woodlands are in decline or are degraded (Bulletin 1). This occurs for many reasons, including grazing by stock, weed invasion, logging and clearing.
Dell, B. +3 more
core +1 more source