Results 61 to 70 of about 55,047 (246)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Research on attenuation rate correlation calibration method based on acoustic variable density logging

Scientific Reports
In order to solve the problem of logging calibration without a free pipe in the process of acoustic variable density logging and the subjective problem of the free pipe calibration method, this paper studies an attenuation rate calibration method based ...
Dongming Liu, Ronghui Yan, Chao Zhou, Lisha Zhang, Pan Zhao, Bing Li, Jun Qin   +6 more
doaj   +1 more source

Research on Key Technology for Perforating 10 000-Metre Deep-Earth Exploration Wells

Cejing jishu
The 10 000-metre deep-earth exploration well shoulders the major tasks of scientific exploration and oil and gas discovery, and has far-reaching significance in the field of ultra-deep oil and gas exploration. In the process of perforating and completing
YU Lei, TANG Kai, CHEN Jianbo, XU Jiale, MA Ziqiang, LI Benchi, LU Yinghui   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Log Evaluation Method and Application of Shale Oil Reservoir in Bongor Basin

Cejing jishu
The evaluation of the main shale oil reservoir in the Baobab block of the Bongor basin, Chad, is insufficient, and a comprehensive method for shale oil resource evaluation is urgently needed.
ZHANG Lihua, QU Peng, HUANG Liang, HOU Qiuyuan, JI Ran, LI Jing   +5 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Application Status and Development Prospect of Coil Tubing Based on Logging Technology

Cejing jishu
With the further development of unconventional oil and gas, the application of coiled tubing in logging has gradually increased, but it still faces challenges such as overlap between logging operations and downhole operations, unclear application ...
ZHOU Yang, NIU Buneng, WANG Zhuo, ZHANG Zhijiang, DU Xu, JIANG Long, LIU Ping   +6 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Development and Application of Ultra High Strength Cable forDeep Ten Thousand Meter Wells

Cejing jishu
In response to the challenges of high tension and ultra long signal transmission faced by cable logging in deep 10 000-meter wells, this article adopts a combination of theoretical design, data analysis, and experimental testing.
MA Jianghu, ZHANG Bingjun, ZHANG Haijun, YANG Qingjian, SHUAI Shichen, LUO Shengqiang, YOU Zhanhua, SUN Wei, JIANG Songhan   +8 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source