Results 111 to 120 of about 80,361 (310)

A Study on the Filtering Method of Natural Gamma Energy Spectrum Logging Data for Low-Count Features [PDF]

open access: yes
The natural radioactivity intensity of rocks is low, and the energy spectrum count measured by natural gamma spectrum logging is low. The low count characteristic magnifies the influence of random error of formation decay, resulting in poor quality of ...
ZHU Qian   +6 more
core   +1 more source

The Data Supplement Method of Azimuthal EM LWD Based on Deep Learning

open access: yesIEEE Access
The data of azimuthal electromagnetic (EM) Logging-While-Drilling (LWD) tool is crucial for controlling and optimizing the trajectory of the wellbore, making it a key technology in geosteering.
Liangchen Zhang   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Estimating Post-Logging Changes in Forest Biomass from Annual Satellite Imagery Based on an Efficient Forest Dynamic and Radiative Transfer Coupled Model

open access: yesRemote Sensing
The abundant satellite data have enabled the study of the dynamics of forest logging and its corresponding carbon balance with remote sensing. Change detection techniques with moderate-resolution imagery have been widely developed.
Xiaoyao Li   +6 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Recent Advances in Data Logging for Intertidal Ecology

open access: yesFrontiers in Ecology and Evolution, 2018
Temperature is among the most ubiquitous determinants of organism growth, survival, and reproduction. Accurate recordings and predictions of how the temperatures of plants and animals vary in time and space are therefore critical to forecasting the ...
Richard Judge   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

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