Results 61 to 70 of about 335,963 (247)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Screening results on the chips made by Algol-multipurpose chipper
Silva Fennica, 1977 The first part of this paper consists of a study based on the available literature concerning the analysis of chip quality in the sulphate pulp process and the factors having an effect on chip quality. Using the empirical material, the suitability of the
Mäkelä, Markku
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Productivity of a prototype truck-mounted logging residue bundler and a road-side bundling system
Silva Fennica, 2010 When recovering logging residues (LR) for bioenergy its density should be increased before road transport, otherwise a low proportion of the trucksâ load capacity will be used.
Lindroos, Ola +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Recovering logging residue: experiences from the Italian Eastern Alps
Croatian Journal of Forest Engineering, 2007 Conducted within the scope of a larger Italian project, the study analyzes three recovery alternatives for logging residue and identifies the conditions that make one preferable to the others.
Raffaele Spinelli +2 more
doaj +2 more sources
Analysis of soft factors that affect the production of logging residue from cutting area to landing in the Sveaskog organisation [PDF]
, 2011 Biofuels are getting more important as EU plans to replace fossil fuels with renewable energy sources. Because of that Sveaskog has chosen to invest in developing the handling process of logging residue. The company has a joined organisation for handling
Ljunglöf, Jenni
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source