Results 51 to 60 of about 335,963 (247)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Considerations on Potentials, Greenhouse Gas, and Energy Performance of Biofuels Based on Forest Residues for Heavy-Duty Road Transport in Sweden

open access: yesEnergies, 2020
This case study investigates the potentials, greenhouse gas (GHG), and energy performance of forest residue biofuels produced by new and emerging production technologies, which are commercially implemented in Sweden for heavy transport.
Shveta Soam, Pål Börjesson
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Impact of forest biomass for energy harvesting on soil compaction - Irish case study

open access: yesJournal of Forest Science, 2014
An assessment of soil compaction caused by machinery used in stump and/or logging residue extraction for energy on soils typical of Ireland. We determined unaffected soil conditions and to find the compaction grade after timber harvesting and bundling ...
J. Pohořalý   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Climate and air pollution impacts of generating biopower from forest management residues in California

open access: yesEnvironmental Research Letters, 2023
California faces crisis conditions on its forested landscapes. A century of aggressive logging and fire suppression in combination with conditions exacerbated by climate change have created an ongoing ecological, economic, and public health emergency ...
Kevin R Fingerman   +13 more
doaj   +1 more source

Summer and fall use of logging residue piles by female short-tailed weasels

open access: yes, 2002
Female short-tailed weasels (Mustela erminea) used piles of logging residue more than expected and used areas without logging residue less than expected when they were in 3-year- old regenerating aspen (Populus tremuloides) cutblocks during summer and ...
Lisgo, Kimberly A.   +2 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Supply Potential and Cost of Residual Forest Biomass for New Industrial Applications in Sweden

open access: yesGCB Bioenergy
This work investigates the potential for logging residues (branches and tops that can be extracted during roundwood harvesting) to replace fossil‐based feedstocks and energy use in industry, using Sweden as a case study.
Sebastian Karlsson   +5 more
doaj   +1 more source

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