Results 61 to 70 of about 2,801 (224)
Philippe Capelle-Dumont et Yannick Courtel (dirs), Religion et liberté [PDF]
, 2017 The present article is published in Proche-Orient Chrétien, N.66, VOL.3-4, JAN. 2017, USJ: Beirut, pp. 425-430. It is a philosophical review of Philippe Capelle-Dumont and Yannick Courtel book “Religion et Liberté” that fetches the records of the First ...
El Asmar Bou Aoun, Marguerite
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Boethius and the Block Universe: Physical and Metaphysical Considerations of Time [PDF]
, 2012 In this exploration of the nature of time, the author shows that more than a superficial belief in a creator God invites the person of faith to engage with some of the unsettling questions presented by modern physics and cosmology. He considers how human
Kerr, S.O.Sc., John Maxwell
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Space environmental considerations for a long-term cryogenic storage vessel [PDF]
Information is given on the kind of protection that is needed against impact and perforation of a long-term cryogenic storage vessel in space by meteoroids and space debris.
Nakanishi, Shigeo
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A classical algorithm to break through Maskin's theorem for small-scale cases [PDF]
Quantum mechanics has been applied to game theory for years. A recent work [H. Wu, Quantum mechanism helps agents combat ``bad'' social choice rules. \emph{International Journal of Quantum Information}, 2010 (accepted). Also see http://arxiv.org/pdf/1002.
Wu, Haoyang
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