Results 61 to 70 of about 531 (230)
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
A broad review on non-intrusive active user authentication in biometrics. [PDF]
J Ambient Intell Humaniz Comput, 2023 Thomas PA, Preetha Mathew K.
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A Body without a Lamp. The Pre-Lucan Pragmatics of the Instruction in Luke 11:34–36
, 2023 Das Logion in Lk 11,34–36 bleibt im literarischen Zusammenhang des Evangeli-ums sperrig, weil der situative Kontext nicht tradiert wurde. Während Lk 11,34 den Einfluss der moralischen Disposition auf die anatomische Sehfähigkeit beschreibt, thematisiert ...
Schmidt, Karl Matthias
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Pauline Allusions to the Sayings of Jesus [PDF]
, 1961 The Catholic Biblical Quarterly, (January 1961), under this heading, subjects the problem of Paul’s allusions to sayings of Jesus to a critical but constructive scrutiny, examining not only specific allusions to some logion of Jesus but also entire ...
Mueller, John Theodore
core
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
'Fuego he venido a traer a la tierra' (Lc 12,49-53): estudio bíblico [PDF]
, 1999 Este sorprendente logion ha sido objeto de múltiples intentos de explicación. En la Biblia, el friego aparece íntimamente ligado a la realidad de Dios. El AT anuncia que habrá friego en la tierra "en el día de la cuenta".
Fernández Lago, José, 1944-
core
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source