Results 61 to 70 of about 1,332,847 (317)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser +5 more
wiley +1 more source
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
MRI feature-based discrimination model for prediction of MGMT promoter methylation status in glioma
Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To explore the potential value of expert-identified CT and MRI imaging features in predicting the MGMT promoter methylation status in glioma. Methods A retrospective analysis was conducted in 188 patients in The First Medical Center of Chinese
ZHANG Zhi-zhong +5 more
doaj +1 more source
Post-hoc simulation study of computerized adaptive testing for the Korean Medical Licensing Examination [PDF]
Journal of Educational Evaluation for Health Professions, 2018 Purpose Computerized adaptive testing (CAT) has been adopted in licensing examinations because it improves the efficiency and accuracy of the tests, as shown in many studies.
Dong Gi Seo, Jeongwook Choi
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To explore the factors influencing the severity of acute phase and short-term prognosis of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, and search for potential indicators for assessing disease severity and predicting prognosis ...
YE Rui-xi +5 more
doaj +1 more source
The extreme residuals in logistic regression models [PDF]
, 1985 Goodness of fit tests for logistic regression models using extreme residuals are considered. Moment properties of the Pearson residuals are developed and used to define modified residuals, for the cases when the model fit is made by maximum ...
Al-Sarraf, Z, Young, D H
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source