Results 71 to 80 of about 92,516 (268)
Advanced Science, EarlyView.Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan +11 more
wiley +1 more source
Factores determinantes de la actividad en el mercado laboral gallego. Influencia del género [PDF]
Aposta, 2013 En este trabajo se estudian las características personales que determinan la actividad (ocupación o paro) en la población gallega. Para ello se construye el modelo de actividad, en el cual se estima la probabilidad de que una persona en edad de trabajar
Mª Carmen Sánchez Sellero
doaj
Advanced Science, EarlyView.SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio +6 more
wiley +1 more source
METHODS FOR REFINING ASSESSMENT OF TEST-TAKERS BASED ON ITEM RESPONSE THEORY MODEL
TASK Quarterly, 2011 This research is devoted to assessment methods used in different test systems, including e-learning systems. The methods considered here are based on classical test theory and item response theory (IRT).
OLEKSANDR SOKOLOV +2 more
doaj
Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization
Advanced Science, EarlyView.A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley +1 more source
The Anáhuac JournalEn este artículo se analiza el efecto marginal de diversas variables socioeconómicas sobre la probabilidad condicional de que un propietario de negocio presente algún grado de inclusión financiera.
Miguel Ángel Rendón Valdés +1 more
doaj +1 more source
Advanced Science, EarlyView.Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui +3 more
wiley +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance
Advanced Science, EarlyView.Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng +12 more
wiley +1 more source
Pesquimat, 2017 La presente investigación tiene como objetivo mostrar la aplicación del método bootstrap dentro del proceso de estimación de la disposición a pagar (DAP) de un determinado bien y/o servicio ambiental, bajo el enfoque de la valoración contingente de ...
Luis Ledesma Goyzueta +1 more
doaj +1 more source