Results 41 to 50 of about 114,027 (300)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
THE VALUE CHAIN AND THE BENEFITS OF ERGONOMICS PROJECTS [PDF]
Management & Marketing, 2007 Nowadays the most competitive companies are always innovative, renewable and able to be ‘the best’ in something. But what does one of the most important resources – the human resource – need to achieve a high level of success in his or her workplace?
Emma LÓGÓ
doaj
Layout optimization of disks by the use of rigid-plastic element model
Computer Assisted Methods in Engineering and Science, 2023 In the paper, the layout optimization of rigid-plastic disks is presented. The method is based on a model where a disk is subdivided into rectangular elements interconnected by normal and shear forces along their edges.
Sándor Kaliszky, János Lógó
doaj
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Communications, 2014 This article is dedicated to corporate design and its impact on online users. It contains definitions of basic concepts and terms of corporate identity. Particular attention is then paid to corporate design and its features - name of the company, slogan,
Radovan Madlenak +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
Marketing research and place image
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2006 The paper deals with some problems of the image and identity of two towns (Brno and Zlín) as well as the whole country (Czech Republic). It starts with theoretical explanation of terms place image, identity and culture and its interrelated influences ...
Miroslav Foret, V. Foretová
doaj +1 more source
Advanced Functional Materials, EarlyView.Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi +7 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A transparent, laser‐microscribed glass platform enables cancer diagnosis within 1 h—much faster than histology, which takes days, and free from the chemical or contrast risks of MRI or CT scans. The antibody‐functionalized rough glass surface captures viable cancer cells directly from suspension, allowing instant optical readout and offering a rapid ...
Anish Pal +5 more
wiley +1 more source
Seymour Papert and Us. Constructionism as the Educational Philosophy of the 21st Century
Вопросы образования, 2017 Seymour Papert — a major philosopher of education, a great educator of modern age, and the father of constructionism — passed away in summer 2016.
Alexei Semenov
doaj +1 more source